Prostate cancer: towards the standardization and synthesis of morphology, genetics, and prognosis
Dan Berney
Department of Medical Oncology, Barts Cancer Centre, Barts and the London School of Medicine and Dentistry, London, UK
Search for more papers by this authorLiang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Search for more papers by this authorDan Berney
Department of Medical Oncology, Barts Cancer Centre, Barts and the London School of Medicine and Dentistry, London, UK
Search for more papers by this authorLiang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Search for more papers by this authorAbstract
Berney D & Cheng L (2012) Histopathology 60, 1–3 Prostate cancer: towards the standardization and synthesis of morphology, genetics, and prognosis
Prostate cancer research and diagnosis is undergoing a revolution in our understanding of the disease process and standardization of diagnostic criteria. Although great progress has been made, there remain many areas of uncertainty and debate. The revolution towards a synthesis of pathology with genetic changes and prognostic models is only just beginning. This supplement presents the opinions and findings of leading international experts in histopathology and prostate research dealing with subjects ranging from aetiology, basic anatomy and morphology to prognostic models, genetic changes and new drug treatments. We hope that this exciting and rapidly changing field will capture the imagination of both experienced and trainee pathologists to advance the field in both research and diagnosis.
References
- 1 Eeles RA , Kote-Jarai Z , Al Olama AA et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study . Nat. Genet. 2009 ; 41 ; 1116 – 1121 .
- 2 Mao X , Yu Y , Boyd LK et al. Distinct genomic alterations in prostate cancers in Chinese and Western populations suggest alternative pathways of prostate carcinogenesis . Cancer Res. 2010 ; 70 ; 5207 – 5212 .
- 3 Tomlins SA , Rhodes DR , Perner S et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer . Science 2005 ; 310 ; 644 – 648 .
- 4 Andriole GL , Crawford ED , Grubb RL 3rd et al. Mortality results from a randomized prostate-cancer screening trial . N. Engl. J. Med. 2009 ; 360 ; 1310 – 1319 .
- 5 Schroder FH , Hugosson J , Roobol MJ et al. Screening and prostate-cancer mortality in a randomized European study . N. Engl. J. Med. 2009 ; 360 ; 1320 – 1328 .
- 6 Ahmed HU , Zacharakis E , Dudderidge T et al. High-intensity-focused ultrasound in the treatment of primary prostate cancer: the first UK series . Br. J. Cancer 2009 ; 101 ; 19 – 26 .
- 7 Epstein JI , Allsbrook WC Jr , Amin MB , Egevad LL . The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma . Am. J. Surg. Pathol. 2005 ; 29 ; 1228 – 1242 .
- 8 Egevad L , Srigley JR , Delahunt B . International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens: rationale and organization . Mod. Pathol. 2011 ; 24 ; 1 – 5 .
- 9 Delahunt BM , Miller RJ , Srigley JR , Evans AJ , Samaratunga H . Gleason grading, past, present and future . Histopathology 2012 ; 60 ; 75 – 86 .
- 10 Egevad L . Handling of radical prostatectomy specimens . Histopathology 2012 ; 60 ; 118 – 124 .
- 11 Epstein JI . Diagnosis of limited adenocarcinoma of the prostate . Histopathology 2012 ; 60 ; 28 – 40 .
- 12 Montironi R , Scarpelli M , Mazzucchelli R , Cheng L , Lopez-Beltran A . The spectrum of morphology in non-neoplastic prostate including cancer mimics . Histopathology 2012 ; 60 ; 41 – 58 .
- 13 Humphrey PA . Histologic variants of prostate carcinoma and their significance . Histopathology 2012 ; 60 ; 59 – 74 .
- 14 Paner G , Aron M , Hansel D , Amin MB . Non-epithelial neoplasms of the prostate . Histopathology 2012 ; 60 ; 166 – 186 .
- 15 Cheng L , Montironi R , Bostwick D , Lopez-Beltran A , Berney DM . Staging of prostate cancer . Histopathology 2012 ; 60 ; 87 – 117 .
- 16 Srigley JR , Delahunt B , Evans AJ . Therapy-associated effects in the prostate gland . Histopathology 2012 ; 60 ; 153 – 165 .
- 17 Fine SW , Reuter VE . Anatomy of the prostate revisited: implications for prostate biopsy and zonal origins of prostate cancer . Histopathology 2012 ; 60 ; 142 – 152 .
- 18 Bostwick DG , Cheng L . Precursors of prostate cancer . Histopathology 2012 ; 60 ; 4 – 27 .
- 19 Sfanos K , DeMarzo A . Prostate cancer and inflammation: the evidence . Histopathology 2012 ; 60 ; 199 – 215 .
- 20 Kristiansen G . Diagnostic and prognostic molecular biomarkers for prostate cancer . Histopathology 2012 ; 60 ; 125 – 141 .
- 21 Barbieri C , Demichelis F , Rubin MA . Molecular genetics of prostate cancer: emerging appreciation of genetic complexity . Histopathology 2012 ; 60 ; 187 – 198 .
- 22 Gleave M . Targeted therapy in prostate cancer . Histopathology 2012 ; 60 ; 216 – 231 .
Citing Literature
