European Journal of Clinical Investigation

Volume 41, Issue 1 pp. 93-97

Evaluation of serum parathyroid hormone-related peptide in hyperthyroid patients

Luca Giovanella,

Luca Giovanella

Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

Clinical Chemistry and Laboratory Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland

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Sergio Suriano,

Sergio Suriano

Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

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Franco Keller,

Franco Keller

Clinical Chemistry and Laboratory Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland

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Giorgio Borretta,

Giorgio Borretta

Endocrinology and Metabolic Diseases, Azienda Ospedaliera ‘Santa Croce e Carle’, Cuneo, Italy

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Luca Ceriani,

Luca Ceriani

Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

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Luca Giovanella,

Luca Giovanella

Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

Clinical Chemistry and Laboratory Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland

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Sergio Suriano,

Sergio Suriano

Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

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Franco Keller,

Franco Keller

Clinical Chemistry and Laboratory Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland

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Giorgio Borretta,

Giorgio Borretta

Endocrinology and Metabolic Diseases, Azienda Ospedaliera ‘Santa Croce e Carle’, Cuneo, Italy

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Luca Ceriani,

Luca Ceriani

Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

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First published: 28 September 2010

https://doi.org/10.1111/j.1365-2362.2010.02385.x

Citations: 2

Luca Giovanella, Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona CH-6500, Switzerland. Tel.: +41 91 8118672; fax: +41 91 8118250; e-mail: [email protected]

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Abstract

Eur J Clin Invest 2010; 41 (1): 93–97

Background Hypercalcemia occurs in 10–20% of patients with hyperthyroidism, but its pathogenesis is still unclear.

Aim To evaluate changes in parathyroid hormone-related peptide (PTH-rP) concentration in hyperthyroid patients compared with healthy controls.

Methods We studied PTH-rP, parathormone (PTH) and ionized calcium levels in 153 hyperthyroid patients, and 89 control subjects. These variables were revaluated after attainment of euthyroidism with the antithyroid drug carbimazole for 6 months in a subgroup of 47 patients.

Results Pretreatment PTH-rP and ionized calcium level were significantly higher in hyperthyroid patients than in controls, whereas an opposite trend occurred for PTH. All parameters normalized after carbimazole therapy.

Conclusion Untreated hyperthyroid patients exhibited a significant elevation in serum ionized calcium and PTH-rP and a significant reduction in serum PTH levels when compared with healthy controls. Our data favoured the hypothesis of a direct involvement of PTH-rP in the pathogenesis of hypercalcemia in hyperthyroid patients.

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Volume41, Issue1

January 2011

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Evaluation of serum parathyroid hormone-related peptide in hyperthyroid patients

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