Article
Full Access
Neural regulation of pancreatic hormone secretion
J.J. Holst,
J.J. Holst
Institute of Medical Physiology C, the Panum Institute, University of Copenhagen, Denmark
Search for more papers by this authorJ.J. Holst,
J.J. Holst
Institute of Medical Physiology C, the Panum Institute, University of Copenhagen, Denmark
Search for more papers by this author
References
- Adrian T.E., Besterman H.S. & Bloom S.R. (1979) The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man. Life Sci 24, 1989–94.
- Andersson P.-O., Holst J. & Järhult J (1979) Role of the sympathoadrenal system in the control of the endocrine pancreas during hemorrhage in cats. Eur Surg Res 11, 409–22.
- Andersson P.-O., Holst J.J., Järhult J. (1982a) Effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats. Acta Physiol Scand 116, 403–9.
- Andersson P.-O., Farnebo L-O., Fredholm B.B., Hamberger B., Holst J. & Järhult J. (1982b) Metabolic and hormonal adjustments during hemorrhage in cats after interference with the sympathoadrenal system. Acta Physiol Scand 114, 111–19.
- Bereiter D.A., Rohner-Jeanrenaud F., Berthoud H.-R. & Jeanrenaud B. (1981) CNS modulation of pancreatic endocrine function. Multiple modes of expression. Diabetolgia 20 (suppl) 417–25.
- Berthoud H.-R., Bereiter D.A., Trimble E.R., Siegel E.G. & Jeanrenaud B. (1981) Cephalic phase, reflex insulin secretion. Neuroanatomical and physiological consideration. Diabetologia 20 (suppl) 393–401.
- Berthoud H.R., Trimble E.R., Siegel E.G., Bereiter D.A. & Jeanrenaud B. (1980) Cephalic-phase insulin secretion in normal and pancreatic islet transplated rats. Am J Physiol 238, E 336–340.
- Bloom S.R., Daniel P.M., Johnston D.I., Ogawa O. & Pratt O.E. (1973). Release of glucagon induced by stress. Quart J Exp Physiol 58, 99–108.
- Bloom S.R., Edwards A.V. & Hardy R.N. (1978) The role of the autonomic nervous system in the control of glucagon, insulin and pancreatic polypeptide release from the pancreas. J Physiol 280, 9–23.
- Cryer P.E. (1983) Coordinated response of glycogenic hormones to central glucopenia: the role of the sympathoadrenal system. Adv Metab Dis 10, 469–84.
- Fischer U, Nowak W., Freyse E-J, Hommel H., Sill U., ÄLippert H. (1982) The influence of selective pancreatic denervation on plasma insulin and glucose tolerance in dogs. Diabete et Metabolisme 2, 115–20.
- Frohmann L. A., Ezdinli E.Z. & Javid R. (1967) Effect of vagotomy and vagal stimulation on insulin secretion. Diabetes 16 443–48.
- Galbo H. (1983) Hormonal and Metabolic Adaptation to Exercise. Thieme, Stuttgart.
- Hilsted J., Madsbad S., Krarup T., Tronier B., Galbo H., Sestoft L. & Schwartz T.W. (1982) No response of pancreatic hormones to hypoglycemia in diabetic autonomic neuropathy. J Clin Endocrinol Metab 54 815–19.
- Holst J.J., Grønholt R., Schaffalitzky de Muckadell O.B. & Fahrenkrug J. (1981a) Nervous control of pancreatic endocrine secretion in pigs I. The insulin and glucagon responses to electrical stimulation of the vagus nerves. Acta Physiol Scand 111 1–7.
- Holst J.J., Grønholt R., Schaffalitzky de Muckadell O.B. & Fahrenkrug J. (1981b) Nervous control of pancreatic endocrine secretion in pigs. V. Influence of the sympathetic nervous system on the pancreatic secretion of insulin and glucagon, and on the insulin and glucagon responses to vagal stimulation. Acta Physiol Scand 113 279–83.
- Holst J.J., Sottimano C., Olesen M., Jensen S.L. & Nielsen O.V. (1981c) Nervous control of gastro-pancreatic somatostatin secretion in pigs. Peptides 2 (suppl 2) 215–22.
- Holst J.J., Schaffalitzky de Muckadell O.B., Fahrenkrug J., Lindkasr S., Nielsen O.W. & Schwartz T.W. (1981) Nervous control of pancreatic secretion of insulin and glucagon. 111. The effect of acetylcholine on the pancreatic secretion of insulin and glucagon. Acta Physiol Scand 111, 15–22.
- Holst J.J., Jensen S.L., Schaffalitzky de Muckadell O.B. & Fahrenkrug J. (1981e) Secretin and vasoactive intestinal polypeptide in the control of the endocrine pancreas. Front Hormone Res 7 119–31.
10.1159/000388393 Google Scholar
- Holst J.J., Knuthsen S., Fahrenkrug J, Jensen S.L., Schwartz T.W., Nielsen O.V., Rehfeld J.F. (1982) Regulatory peptides in the neural control of the pancreas. Symposia Medica Hoechst 18, 171–93.
- Holst J.J., Jensen S.L., Knuhtsen S., Nielsen O.V. (1983) Autonomic nervous control of pancreatic somatostatin secretion. Am J Physiol 245 E542–48.
- Holst J.J., Knuhtsen S., Jensen S.L., Nielsen O.V., Schwartz T. W. (1983b) GRP-nerves in the control of pancreatic endocrine secretion. Diabetologia 25, 165.
- Holst J.J., Fahrenkrug J., Knuhtsen S., Jensen S.L., Poulsen S.S., Nielsen O.V. (1984) Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion. Regulatory Peptides 8, 245–59.
- Holst J.J., Fahrenkrug J., Jensen S.L., Nielsen O.V. (1984b) PHI/VIP in the pig pancreas: Co-translation, Co-esistence and Co-secretion and co-operative effects. Dig Dis Sci 29 (suppl), 37S.
- Håkanson R., Ekblad E., Wahlested C., Edvinsson L. & Sundler F. (1984) Neuropeptide Y coexists with noradrenaline in perivascular nerve fibres and potentiates vasoconstriction ny noradrenaline and histaamine. Dig Dis Sci 29 (suppl) 34s.
- Issekutz B. (1980) The role of hypoinsulinemia in exercise metabolism. Diabetes 29 629–35.
- Järhult & Holst J.J. (1978) Reflex adrenergic control of endocrine pancreas evoked by unloading of carotid baroreceptors in cats. Acta Physiol Scand 104 188–202.
- Järhult J. & Holst J. (1979) The role of the adrenergic innervation to the pancreatic islets in the control of insulin release during exercise in man. Pflügers Arch 383 41–45.
- Järhult J., Andersson P.-O., Holst J., Moghimzadeh E. & Nobin A. (1980) On the sympathetic innervation to the cats's liver and its role for hepatic glucose release. Acta Physiol Scand 108, 5–11.
10.1111/j.1748-1716.1980.tb06623.x Google Scholar
- Knuhtsen S., Holst J.J., Knigge U., Olesen M. & Nielsen O.V. (1984) Radioimmunoassay, pharmacokinetics and neuronal release of gastrin releasing peptide in anesthetized pigs. Gastroenterology 87, 372–378.
- Lundberg J.M., Terenius L., Hökfelt T. & Goldstein M. (1983) High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Let 42, 167–72.
- Lundberg J.μ. & Hökfelt T. (1983) Coexistence of peptides and classical neurotransmitters. Trends Neurosci 6, 325–33.
- Lundberg J.M., Fahrenkrug J., Hökfelt T., Martling C-R., Larsson O., Tatemoto K. & Anggård A. (1984) Co-Existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man. Peptides 5, 593–606.
- McDonald T.J. (1981) Non-amphibian bombesin-like peptides. In: S.R. Bloom & J.M. Polak (eds). Gut Hormones, 2nd edn, 407–12. Churchill Livingstone, Edinburgh.
- Rehfeld J.F., Larsson L-I., Goltermann N.R., Schwartz T.W., Holst J.J., Jensen S.L., Morley J.S. (1980) Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK. Nature 284, 33–38.
- Rohner-Jeanrenaud F., Bobbioni E., Ionescu E., Sauter J.-F. & Jeanrenaud B. (1983) Central nervous system regulation of insulin secretion. Adv Metab Dis 10, 193–219.
- Samols E. & Weir G. (1979) Adrenergic modulation of pancreatic A, B, and D cells. J Clin Invest 63 230–38.
- Schatz H. & Kullek U. (1980) Studies on the local (paracrine) actions of glucagon, somatostatin and insulin in isolated islets of rat pancreas. FEBSlett 122, 207–10.
- Schöön Ι-M., Sjöström L., Holst J.J., Schwartz T.W. & Olbe L. (1980) The effect of antral distension on the endocrine pancreas in man. Scand J Gastroenterol 15, 811–16.
- Schwartz T.W., Stenquist B. & Olbe L. (1979) Cephalic phase of pancreatic polypeptide secretion studied by sham feeding in man. Scand J Gastroenterol 14, 313–20.
- Schwartz T.W. (1983) Pancreatic polypeptide. A hormone under vagal control. Gastroenterol 85, 1411–25.
- Shimazu T. (1983) Reciprocal innervation of the liver: its significane in metabolic control. Adv Metab Dis 10, 355–84.
- Smith P.H. & Davis B.J. (1983) Morphological and functional aspects of pancreatic islet innervation. J Autonom Nerv Syst 9, 53–66.
- Steffens A.B. & Strubbe J.H. (1983) CNS regulation of glucagon secretion. Adv Metab Dis 10, 221–58.
- Tatemoto K. (1981) Neuropeptide Y: Complete aminoacid sequence of the brain peptide. Proc Natl Acad Sci USA 79, 5485–89.
- Wood S.M., Polak J.M., Bloom S.R. (1983) Neuropeptides in the control of the islets of Langerhans. Adv Metab Dis 10, 401–20.
- Woods S.C. & Porte D. (1974) Neural control of the endocrine pancreas. Physiol Rev 54, 596–620.