CIRCULATING CATECHOLAMINE, THYROTROPHIN, THYROID HORMONE AND PROLACTIN RESPONSES OF NORMAL SUBJECTS TO ACUTE COLD EXPOSURE
Corresponding Author
B. P. O'MALLEY
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Dr B. P. O'Malley, Department of Clinical Pharmacology, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.Search for more papers by this authorN. COOK
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorA. RICHARDSON
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorD. B. BARNETT
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorF. D. ROSENTHAL
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorCorresponding Author
B. P. O'MALLEY
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Dr B. P. O'Malley, Department of Clinical Pharmacology, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.Search for more papers by this authorN. COOK
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorA. RICHARDSON
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorD. B. BARNETT
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorF. D. ROSENTHAL
Department of Pharmacology and Therapeutics, University of Leicester and The Leicester Royal Infirmary, Leicester
Search for more papers by this authorSUMMARY
The responses of circulating catecholamines, TSH, thyroid hormones and prolactin to 30 min of acute cold exposure (4°C) were measured in eight normal volunteers over a 2 h period. There was a rise in circulating noradrenaline, TSH, T4 and T3 levels and a fall in circulating prolactin in the subjects studied, but no change in circulating adrenaline levels nor any alteration in the T4/T3 ratio. The thyroid axis of normal individuals can respond rapidly to acute cold exposure. In addition, the increased plasma noradrenaline levels accompanied by unaltered adrenaline levels suggest that the stimulus exerted by cold does not evoke a generalised stress response, but rather that the sympathetic nervous system is selectively stimulated.
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