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Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors

Corresponding Author

Janet D. Littlewood

University of Cambridge, Department of Clinical Veterinary Medicine, Madingley Road, Cambridge

Animal Health Trust, Newmarket, Sufolk

Dr Janet D. Littlewood, Animal Health Trust, P.O. Box 5, Newmarket, Suffolk CB8 7DW.Search for more papers by this author

Sally A. Bevan,

Sally A. Bevan

Animal Health Trust, Newmarket, Sufolk

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Geoffrey Kemball-Cook,

Geoffrey Kemball-Cook

National Institute of Biological Standards and Control South Mymms, Potters Bar, Herts.

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Richard J. Evans,

Richard J. Evans

University of Cambridge, Department of Clinical Veterinary Medicine, Madingley Road, Cambridge

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Trevor W. Barrowcliffe,

Trevor W. Barrowcliffe

National Institute of Biological Standards and Control South Mymms, Potters Bar, Herts.

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Janet D. Littlewood,

Corresponding Author

Janet D. Littlewood

University of Cambridge, Department of Clinical Veterinary Medicine, Madingley Road, Cambridge

Animal Health Trust, Newmarket, Sufolk

Dr Janet D. Littlewood, Animal Health Trust, P.O. Box 5, Newmarket, Suffolk CB8 7DW.Search for more papers by this author

Sally A. Bevan,

Sally A. Bevan

Animal Health Trust, Newmarket, Sufolk

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Geoffrey Kemball-Cook,

Geoffrey Kemball-Cook

National Institute of Biological Standards and Control South Mymms, Potters Bar, Herts.

Search for more papers by this author

Richard J. Evans,

Richard J. Evans

University of Cambridge, Department of Clinical Veterinary Medicine, Madingley Road, Cambridge

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Trevor W. Barrowcliffe,

Trevor W. Barrowcliffe

National Institute of Biological Standards and Control South Mymms, Potters Bar, Herts.

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First published: April 1991

https://doi.org/10.1111/j.1365-2141.1991.tb08622.x

Citations: 12

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Abstract

Summary. The source of human factor VIIII (FVIII) had a marked effect on the inhibitory activity of a panel of eight human FVIII inhibitors. Use of conventional FVIII concentrates gave lower inhibitor titres whereas a monoclonal antibody purified FVIII concentrate gave titres similar to or greater than those with plasma. Addition of phospholipid (PL) protected highly purified FVIII against inhibition. The content of PL-bound FVIII in concentrates may account for the observed differences.

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Volume77, Issue4

April 1991

Pages 535-538

Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors

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Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors

Abstract

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