mdr-1 GENE AMPLIFICATION IN ACUTE LYMPHOBLASTIC LEUKAEMIA PRIOR TO ANTILEUKAEMIC TREATMENT
Mariagrazia Michieli
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorMauro Giacca
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorRenato Fanin
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorDaniela Damiani
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorAntonella Geromin
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorMichele Baccarani
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorMariagrazia Michieli
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorMauro Giacca
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorRenato Fanin
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorDaniela Damiani
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorAntonella Geromin
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this authorMichele Baccarani
Chair of Haematology and Chair of Anatomy, Institute of Experimental and Clinical Morphology, University of Udine School of Medicine, Udine, and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Search for more papers by this author
References
- Chen, C., Clark, D., Ueda, K., Pastan, I., Gottesman, M.M. & Roninson, I.B. (1990) Genomic organization of the human multidrug resistance (mdr-1) gene and origin of P-glycoproteins. Journal of Biological Chemistry, 265, 506–514.
- Deuchars, K.L. & Ling, V. (1989) P-glycoprotein and multidrug resistance in cancer chemotherapy. Seminars in Oncology, 16, 156–165.
- Fojo, A.T., Ueda, K., Slamon, D.J., Poplack, D.G., Gottesman, M.M. & Pastan, I. (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proceeding of the National Academy of Sciences of the United States of America, 84, 265–269.
- Hamada, H. & Tsuruo, T. (1986) Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cell as revealed by monoclonal antibodies. Proceeding of the National Academy of Sciences of the United States of America, 83, 7785–7789.
- Holmes, J., Jacobs, A., Carter, G., Janowska-Wieczorek, A. & Padua, R.A. (1989) Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia. British Journal of Haematology, 72, 40–44.
- Kartner, N., Evernden-Porelle, D., Bradley, G. & Ling, V. (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature, 316, 820–823.
- Pastan, I. & Gottesman, M. (1987) Multiple-drug resistance in human cancer. New England Journal of Medicine, 316, 1388–1393.
- Rothenberg, M.L., Mickley, L.A., Cole, D.E., Balis, F.M., Tsuruo, T., Poplack, D.G. & Fojo, A.T. (1989) Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia. Blood, 74, 1388–1395.
- Shen, D.W., Fojo, A., Chin, J.E., Roninson, I.B., Richert, N., Pastan, I. & Gottesman, M.M. (1986) Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science, 232, 643–645.