Cutaneous graft-versus-host-like histology in childhood. Importance of clonality analysis in differential diagnosis. A case report
A. D’hauw, M.M.B. Seyger, P.J.T.A. Groenen, C.M.R. Weemaes,
A. Warris,
W.A.M. Blokx,
C.M.R. Weemaes
Paediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands Correspondence: W.A.M. Blokx.E-mail: [email protected]
Search for more papers by this authorA. Warris
Paediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands Correspondence: W.A.M. Blokx.E-mail: [email protected]
Search for more papers by this authorA. D’hauw, M.M.B. Seyger, P.J.T.A. Groenen, C.M.R. Weemaes,
A. Warris,
W.A.M. Blokx,
C.M.R. Weemaes
Paediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands Correspondence: W.A.M. Blokx.E-mail: [email protected]
Search for more papers by this authorA. Warris
Paediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands Correspondence: W.A.M. Blokx.E-mail: [email protected]
Search for more papers by this authorConflicts of interest: none declared.
References
- 1 Omenn GS. Familial reticuloendotheliosis with eosinophilia. N Engl J Med 1965; 273: 427–32.
- 2 Giliani S, Bonfim C, De Saint Basile G et al. Omenn syndrome in an infant with IL7RA gene mutation. J Pediatr 2006; 148: 272–4.
- 3 Kato M, Kimura H, Seki M et al. Omenn syndrome – review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan. Allergol Int 2006; 55: 115–19.
- 4 Van Dongen JJ, Langerak AW, Bruggemann M et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257–317.
- 5 Noordzij JG, De Bruin-Versteeg S, Verkaik NS et al. The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteins. Blood 2002; 100: 2145–52.
- 6 Noordzij JG, Verkaik NS, Van Der Burg M et al. Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow. Blood 2003; 101: 1446–52.
- 7 Hausser I, Anton-Lamprecht I. Severe congenital generalized exfoliative erythroderma in newborns and infants: a possible sign of Netherton syndrome. Pediatr Dermatol 1996; 13: 183–99.
- 8 Scheimberg I, Hoeger PH, Harper JI et al. Omenn’s syndrome: differential diagnosis in infants with erythroderma and immunodeficiency. Pediatr Dev Pathol 2001; 4: 237–45.
- 9 Heymer B, Friedrich W, Vossbeck S et al. So-called Omenn syndrome. A contribution to pathogenesis and histomorphology. Pathologe 1993; 14: 334–40.
- 10 Jouan H, Le Deist F, Nezelof C. Omenn’s syndrome – pathologic arguments in favor of a graft versus host pathogenesis: a report of nine cases. Hum Pathol 1987; 18: 1101–8.
