Novel substitution and frameshift mutations of CYLD in two Chinese families with multiple familial trichoepithelioma
Y-H. Liang
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Department of Dermatology, First Affiliated Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
Search for more papers by this authorC-S. Sun
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Search for more papers by this authorX-Y. Ye
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Search for more papers by this authorW. Zhang
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Search for more papers by this authorS. Yang
Department of Dermatology, First Affiliated Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
Search for more papers by this authorX-J. Zhang
Department of Dermatology, First Affiliated Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
Search for more papers by this authorY-H. Liang
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Department of Dermatology, First Affiliated Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
Search for more papers by this authorC-S. Sun
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Search for more papers by this authorX-Y. Ye
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Search for more papers by this authorW. Zhang
Department of Dermatology, First Affiliated Hospital, Gannan Medical College, 23 Yixueyuan Road, Ganzhou, Jiangxi 341000, China
Search for more papers by this authorS. Yang
Department of Dermatology, First Affiliated Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
Search for more papers by this authorX-J. Zhang
Department of Dermatology, First Affiliated Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
Search for more papers by this authorConflicts of interest: none declared.
References
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- 3 Saito K, Kigawa T, Koshiba S et al. The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. Structure 2004; 12: 1719–28.
- 4 Trompouki E, Hatzivassiliou E, Tsichritzis T et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 2003; 424: 793–6.
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- 9 Zuo YG, Xu Y, Wang B et al. A novel mutation of CYLD in a Chinese family with multiple familial trichoepithelioma and no CYLD protein expression in the tumour tissue. Br J Dermatol 2007; 157: 818–21.
- 10 Kovalenko A, Chable-Bessia C, Cantarella G et al. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 2003; 424: 801–5.
