Detection of COL1A1–PDGFB fusion transcripts and platelet-derived growth factor α and β receptors in giant cell fibroblastoma of the postsacrococcygeal region
A. Kashima
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorA. Yamashita
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorS. Moriguchi
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorK. Marutsuka
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorS. Tsumori
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorK. Yoshizato
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorA. Ishihara
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorM. Setoyama
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorY. Asada
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorA. Kashima
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorA. Yamashita
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorS. Moriguchi
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorK. Marutsuka
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorS. Tsumori
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorK. Yoshizato
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorA. Ishihara
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorM. Setoyama
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorY. Asada
First Department of Pathology, Department of Dermatology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Departments of *Neurosurgery and †Pathology, Nobeoka Prefectural Hospital, 2-1-10 Shinkoji, Nobeoka, Japan
Search for more papers by this authorConflicts of interest None declared.
Summary
We describe a 2-year-old girl with recurrent giant cell fibroblastoma (GCF) of the postsacrococcygeal region. Both the initial and recurrent tumours contained solid and angiectoid areas. The former was composed of loosely arranged wavy spindle cells and giant cells with a well-vascularized myxoid to collagenous stroma. The angiectoid spaces were often lined by multinucleated giant cells. Immunohistochemically, the tumour cells and small vessels in the tumour tissue were positive for platelet-derived growth factor (PDGF) α and β receptors. Molecular analysis revealed fusion of collagen type Iα1 exon 26 with PDGF-B chain exon 2 that induced unscheduled production of PDGF-BB. These findings suggest that PDGF and its receptors significantly contribute to the development of GCF in both an autocrine and a paracrine manner.
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