Volume 95, Issue 5 pp. 519-524
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Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease

HANS-HENRIK PARVING

Corresponding Author

HANS-HENRIK PARVING

Department of Medicine A, Rigshospitalet, University of Copenhagen, Department of Clinical Physiology, Bispebjerg Hospital, and The Departments of Dermatology and Clinical Physiology, The Finsen Institute, Copenhagen, Denmark

Dr H.-H. Parving, Department of Clinical Physiology, Bispebjerg Hospital, Bispebjerg Bakke, 2400 Copenhagen N.V., Denmark.Search for more papers by this author
ANNE-MARIE WORM

ANNE-MARIE WORM

Department of Medicine A, Rigshospitalet, University of Copenhagen, Department of Clinical Physiology, Bispebjerg Hospital, and The Departments of Dermatology and Clinical Physiology, The Finsen Institute, Copenhagen, Denmark

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NIELS ROSSING

NIELS ROSSING

Department of Medicine A, Rigshospitalet, University of Copenhagen, Department of Clinical Physiology, Bispebjerg Hospital, and The Departments of Dermatology and Clinical Physiology, The Finsen Institute, Copenhagen, Denmark

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First published: November 1976
Citations: 19

SUMMARY

Plasma volume and plasma concentration and transcapillary escape rate of albumin (TERalb), i.e. the fraction of intravascular mass of alhumin that passes to the extravascular space per unit time, were determined using 125I-labelled human albumin in eight patients with extensive skin disease. Plasma volume and plasma alhumin concentration were reduced (P<0.05). Thus the intravascular albumin mass was moderately decreased to an average of 0.55 ± 0.06 (s.d.) g/cm height compared with a normal mean value of 0.77 ± 0.07 (s.d.) g/cm. This 29% decrease is statistically significant (P<0.001). The transcapillary escape rate of alhumin (TERalb) was significantly elevated, mean 8.6 ± 1.1 (s.d.) %× h−1 as compared to normal subjects, mean 5.6 ± 1.1 (s.d.) %× h−1, (+ 54% P<0.001). The same patients were studied again after a 1-week treatment with prednisone, 25–60 mg per day. Plasma albumin concentration, plasma volume and intravascular mass of albumin were unchanged, while TERalb, decreased significantly during treatment, mean 5.9 ± 0.8 (s.d.)%× h−1, (P<0.01).

It is suggested that displacement of albumin into the skin and loss of albumin from the skin are the dominating mechanisms ofthe reduction in the intravascular alhumin mass in patients with extensive skin disease.

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