Comorbid psychiatric disorders and nicotine dependence in adolescence
Pamela C. Griesler,
Mei-Chen Hu,
Christine Schaffran,
Denise B. Kandel,
Pamela C. Griesler
New York State Psychiatric Institute, New York, NY, USA,
Department of Psychiatry, Columbia University, New York, NY, USA
Search for more papers by this authorMei-Chen Hu
Department of Psychiatry, Columbia University, New York, NY, USA
Search for more papers by this authorChristine Schaffran
New York State Psychiatric Institute, New York, NY, USA,
Search for more papers by this authorCorresponding Author
Denise B. Kandel
New York State Psychiatric Institute, New York, NY, USA,
Department of Psychiatry, Columbia University, New York, NY, USA
Mailman School of Public Health, Columbia University, New York, NY, USA
Denise B. Kandel, Columbia University, 1051 Riverside Drive, Unit 20, New York, NY 10032, USA. E-mail: [email protected]Search for more papers by this authorPamela C. Griesler,
Mei-Chen Hu,
Christine Schaffran,
Denise B. Kandel,
Pamela C. Griesler
New York State Psychiatric Institute, New York, NY, USA,
Department of Psychiatry, Columbia University, New York, NY, USA
Search for more papers by this authorMei-Chen Hu
Department of Psychiatry, Columbia University, New York, NY, USA
Search for more papers by this authorChristine Schaffran
New York State Psychiatric Institute, New York, NY, USA,
Search for more papers by this authorCorresponding Author
Denise B. Kandel
New York State Psychiatric Institute, New York, NY, USA,
Department of Psychiatry, Columbia University, New York, NY, USA
Mailman School of Public Health, Columbia University, New York, NY, USA
Denise B. Kandel, Columbia University, 1051 Riverside Drive, Unit 20, New York, NY 10032, USA. E-mail: [email protected]Search for more papers by this authorABSTRACT
Aims To examine bidirectional influences of onset of psychiatric disorders and nicotine dependence among adolescent smokers.
Design A prospective longitudinal cohort of adolescents and mothers drawn from a large city school system. Adolescents were interviewed five times and mothers three times over 2 years.
Setting Chicago, Illinois.
Participants Subsample of adolescent smokers (n = 814).
Measurements Selected DSM-IV psychiatric disorders, nicotine dependence and selected risk factors were ascertained.
Findings Among lifetime smokers, 53.7% experienced at least one nicotine dependence criterion; 26.1% full dependence; 14.1% experienced an anxiety disorder, 18.8% a mood disorder and 29.5% a disruptive disorder. Nicotine dependence and psychiatric disorders were comorbid: nicotine-dependent youths had higher rates of individual and multiple disorders than those not dependent. Controlling for other covariates, mood disorder and nicotine dependence did not predict each other; anxiety disorder predicted nicotine dependence. Bidirectional influences were observed for disruptive disorder and nicotine dependence. Predictors of onset of full nicotine dependence included earlier onset age of tobacco use, high initial pleasant sensitivity to tobacco, alcohol and illicit drug use, abuse and dependence and parental nicotine dependence. Predictors of psychiatric disorder onset included gender, race/ethnicity, other psychiatric disorders, illicit drug abuse or dependence and parental depression and delinquency.
Conclusions Initial pleasant experiences of smoking are predictive of later development of nicotine dependence. There may be reciprocal influences between disruptive disorder and development of nicotine dependence in adolescence, and intergenerational transmission of parental nicotine dependence and psychopathology.
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