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Preclinical in vivo Antitumor Efficacy of Nedaplatin with Gemcitabine against Human Lung Cancer
Mitsunobu Matsumoto,
Yukihiro Takeda,
Hideo Maki,
Kanji Hojo,
Tohru Wada,
Yoshinori Nishitani,
Ryuji Maekawa,
Takayuki Yoshioka,
Mitsunobu Matsumoto
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorYukihiro Takeda
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorHideo Maki
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorKanji Hojo
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorTohru Wada
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorYoshinori Nishitani
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorRyuji Maekawa
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorCorresponding Author
Takayuki Yoshioka
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
To whom correspondence should be addressed. E-mail: [email protected]Search for more papers by this authorMitsunobu Matsumoto,
Yukihiro Takeda,
Hideo Maki,
Kanji Hojo,
Tohru Wada,
Yoshinori Nishitani,
Ryuji Maekawa,
Takayuki Yoshioka,
Mitsunobu Matsumoto
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorYukihiro Takeda
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorHideo Maki
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorKanji Hojo
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorTohru Wada
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorYoshinori Nishitani
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorRyuji Maekawa
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
Search for more papers by this authorCorresponding Author
Takayuki Yoshioka
Shionogi Research Laboratories, Shionogi & Co., Ltd., 5-12-4 Sagisu, Fukushima-ku, Osaka 553-0002
To whom correspondence should be addressed. E-mail: [email protected]Search for more papers by this author
References
- 1 Totani , T. , Aono , K. , Komura , M. . and Adachi , Y. Synthesis of (glycolato-O, O')diammineplatinum (II) and its related complexes . Chem. Lett. , 3 , 429 – 432 ( 1986 ).
- 2 Suzumura , S. , Kato , T. , Ueda , R. . and Ohta , K. Effect of treatment schedule on antitumor activity of glycolato-O, O' diammineplatinum (II), a new platinum derivative: comparison with cw-diamminedichloroplatinum (II) . Anticancer Res. , 9 , 1083 – 1088 ( 1989 ).
- 3 Shiratori , O. , Kasai , H. , Uchida , N. , Takeda , Y. , Totani , T. . and Sato , K. Anti-tumor activity of 254-S, a platinum complex, in rodents . In “Recent Advances in Chemotherapy,” ed. J. Ishigami , pp . 635 – 636 ( 1985 ). University of Tokyo Press , Tokyo .
- 4 Koenuma , M. , Kasai , H. , Uchida , N. , Wada , T. , Hattori , M. , Oguma , T. , Totani , T. . and Inaba , M. Pharmacokinetic correlation between experimental and clinical effects on human non-small cell lung cancers of cis-diammine glycolatoplatinum (254-S) and cis-diammine dichloroplatinum . Anticancer Res. , 15 , 417 – 422 ( 1995 ).
- 5 Kameyama , Y. , Okazaki , N. , Nakagawa , M. , Koshida , H. , Nakamura , M. . and Gemba , M. Nephrotoxicity of a new platinum compound, 254-S, evaluated with rat kidney cortical slices . Toxicol. Lett. , 52 , 15 – 24 ( 1990 ).
- 6 Furuse , K. , Fukuoka , M. , Ohshima , S. , Ariyoshi , Y. , Fujii , M. , Kurita , Y. , Hasegawa , K. , Homma , T. , Tamura , M. , Inoue , S. , Nishiwaki , Y. , Kimura , I. . and Niitani , H. Phase II clinical study of (glycolato-O, O')diammineplatinum (II), a new platinum complex, for primary lung cancer . Proc. Am. Soc. Clin. Oncol. , 8 , 238 ( 1989 ).
- 7 Fukuda , M. , Shinkai , T. , Eguchi , K. , Sasaki , Y. , Tamura , T. , Ohe , Y. , Kojima , A. , Oshita , F. , Hara , K. . and Saijo , N. Phase II study of (glycolato-O, O')diammineplatinum (II), a novel platinum complex, in the treatment of non-small-cell lung cancer . Cancer Chemother. Pharmacol. , 26 , 393 – 396 ( 1990 ).
- 8 Inuyama , Y. , Miyake , H. , Horiuchi , M. , Hayasaki , K. , Komiyama , S. . and Ohta , K. An early phase II study of cis-diammine glycolato platinum, 254-S, for head and neck cancers . Jpn. J. Cancer Chemother. , 19 , 863 – 869 ( 1992 ).
- 9 Akaza , H. , Togashi , M. , Nishio , Y. , Miki , T. , Kotake , T. , Matumura , Y. , Yoshida , O. . and Aso , Y. Phase II study of cw-diammine(glycolato)platinum, 254-S, in patients with advanced germ-cell testicular cancer, prostatic cancer, and transitional-cell carcinoma of the urinary tract . Cancer Chemother. Pharmacol. , 31 , 187 – 192 ( 1992 ).
- 10 Kato , T. , Noda , K. , Hirabayashi , K. . and Nishimura , H. Phase II study of cis-diammine(glycolato)platinum (254-S), a new platinum complex, for gynecological malignancy . Proc. 16th Int. Congr. Chemother., Anticancer Sect. , 823 , 1 – 2 ( 1989 ).
- 11 Uchida , N. , Kasai , H. , Takeda , Y. , Maekawa , R. , Sugita , K. . and Yoshioka , T. Augmented antitumor activity in combination chemotherapy of Nedaplatin with Etoposide . Anti-cancer Res. , 18 , 247 – 252 ( 1998 ).
- 12 Takeda , Y. , Kasai , H. , Uchida , N. , Yoshida , H. , Maekawa , R. , Sugita , K. . and Yoshioka , T. Enhanced antitumor efficacy of nedaplatin with 5-fluorouracil against human squamous carcinoma xenografts . Anticancer Res. , 19 , 4059 – 4064 ( 1999 ).
- 13 Uchida , N. , Yoshida , H. , Yamada , H. , Wada , T. , Daikatsu , K. , Ikeuchi , I. , Maekawa , R. , Sugita , K. . and Yoshioka , T. Combination chemotherapy with nedaplatin and cyclophosphamide in human ovarian cancer model . Jpn. J. Cancer Res. , 90 , 887 – 894 ( 1999 ).
- 14 Braakhuis , B. J. , Guus , A. M. S. , van Dongen , G. A. , Vermorken , J. B. . and Snow , G. B. Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (Gemcitabine) against human head and neck cancer . Cancer Res. , 51 , 211 – 214 ( 1991 ).
- 15 Noble , S. . and Goa , K. L. Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer . Drugs , 54 , 447 – 472 ( 1997 ).
- 16 Hui , Y. F. . and Reitz , J. Gemcitabine. A cytidine analogue active against solid tumors . Am. J. Health Syst. Pharm. , 54 , 162 – 170 ( 1997 ).
- 17 Moore , D. F. , Pazdur , R. , Daugherty , K. , Tarassoff , P. . and Abbruzzese , J. L. Phase II study of gemcitabine in advanced colorectal adenocarcinoma . Invest. New Drugs , 10 , 323 – 325 ( 1992 ).
- 18 Casper , E. S. , Green , M. R. , Kelsen , D. P. , Heelan , R. T. , Brown , T. D. , Flombaum , C. D. , Trochanowski , B. . and Tarassoff , P. G. Phase II trial of gemcitabine (2′,2′-difluo-rodeoxycytidine) in patients with adenocarcinoma of the pancreas . Invest. New Drugs , 12 , 29 – 34 ( 1994 ).
- 19 Anderson , H. , Lund , B. , Bach , F. , Thatcher , N. , Walling , J. . and Hansen , H. H. Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase II study . J. Clin. Oncol. , 12 , 1821 – 1826 ( 1994 ).
- 20 Cormier , Y. , Eisenhauer , E. , Muldal , A. , Gregg , R. , Ayoub , J. , Goss , G. , Stewart , D. , Tarasoff , P. . and Wong , D. Gemcitabine is an active new agent in previously untreated extensive small cell lung cancer (SCLC). A study of the National Cancer Institute of Canada Clinical Trials Group . Ann. Oncol. , 5 , 283 – 285 ( 1994 ).
- 21 Lund , B. , Hansen , O. P. , Theilade , K. , Hansen , M. . and Neijt , J. P. Phase II study of gemcitabine (2′,2′-difluorode-oxycytidine) in previously treated ovarian cancer patients . J. Natl. Cancer Inst , 86 , 1530 – 1533 ( 1994 ).
- 22 Michael , M. . and Moore , M. Clinical experience with gemcitabine in pancreatic carcinoma . Oncology , 11 , 1615 – 1622 ( 1997 ).
- 23 Bergman , A. M. , Ruiz van Haperen , V. W. T. , Veerman , G. , Huiper , M. . and Peters , G. J. Synergistic interaction between cisplatin and gemcitabine in vitro . Clin. Cancer Res. , 2 , 521 – 530 ( 1996 ).
- 24 van Moorsel , C. J. A. , Pinedo , H. M. , Veerman , G. , Bergman , A. M. , Kuiper , C. M. , Vermorken , J. B. , van der Vijgh , W. J. F. . and Peters , G. J. Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines . Br. J. Cancer , 80 , 981 – 990 ( 1999 ).
- 25 Carmichael , J. , Allerheiligen , S. . and Walling , J. Phase I study of gemcitabine and cisplatin in non-small cell lung cancer . Semin. Oncol , 23 , 55 – 59 ( 1996 ).
- 26 Crino , L. , Scagliotti , G. , Marangolo , M. , Figoli , F. , Clerici , M. , de Marinis , F. , Salvati , F. , Cruciani , G. , Dogliotti , L. , Pucci , F. , Paccagnella , A. , Adamo , V. , Altavilla , G. , Incoronato , P. , Trippetti , M. , Mosconi , A. M. , Santucci , A. , Sorbolini , S. , Oliva , C. . and Tonato , M. Cisplatin-gemcita-bine combination in advanced non-small-cell lung cancer: a phase II study . J. Clin. Oncol , 15 , 297 – 303 ( 1997 ).
- 27 Mosconi , A. M. , Crino , L. . and Tonato , M. Combination therapy with gemcitabine in non-small cell lung cancer . Eur. J. Cancer , 33 , S14 – S17 ( 1997 ).
- 28 Anton , A. , Diaz-Fernandez , N. , Gonzalez Larrba , J. L. , Vadell , C. , Masutti , B. , Montalar , J. , Barneto , L , Artal , A. . and Resell , R. Phase II trial assessing the combination of gemcitabine and cisplatin in advanced non-small cell lung cancer (NSCLC) . Lung Cancer , 22 , 139 – 148 ( 1998 ).
- 29 Cartei , G. , Sacco , C. , Sibau , A. , Pella , N. , Lop , A. . and Tabaro , G. Cisplatin and gemcitabine in non-small-cell lung cancer . Ann. Oncol , 10 , S57 – S62 ( 1999 ).
- 30 Cardenal , F. , Lopex-Cabrerizo , M. P. , Anton , A. , Alberola , V. , Massuti , B. , Carrato , A. , Barneto , L , Lomas , M. , Garcia , M. , Lianes , P. , Montalar , J. , Vandell , C. , Gonzalez-Larriba , J. L. , Nguyen , B. , Artal , A. . and Rosell , R. Randomized phase HI study of gemcitabine-cisplatin versus etoposide-cisplatin-etoposide in the treatment of locally advanced or metastatic non-small-cell lung cancer . J. Clin. Oncol. , 17 , 12 – 18 ( 1999 ).
- 31 Langer , C. J. , Gandara , D. R. , Calvert , P. , Edelman , M. J. . and Ozols , R. F. Gemcitabine and carboplatin: an update of Phase I and II studies in non-small cell lung cancer . Semin. Oncol. , 26 , 12 – 18 ( 1999 ).
- 32 Wallenstein , S. , Zucker , C. L. . and Fleis , J. L. Some statistical methods useful in circulation research . Circ. Res. , 47 , 1 – 9 ( 1980 ).
- 33 Dunnett , C. W. New tables for multiple comparisons with a control . Biometrics , 20 , 482 – 491 ( 1964 ).
- 34 Braakhuis , B. J. M. , Ruiz van Haperen , V. W. T. , Welters , M. J. P. . and Peters , G. J. Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts . Chem. Eur. J. Cancer , 31A , 2335 – 2340 ( 1995 ).
- 35 van Moorsel , C. J. A. , Pinedo , H. M. , Veerman , G. , Vermorken , J. B. , Postmus , P. E. . and Peters , G. J. Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice . Eur. J. Cancer , 35 , 808 – 814 ( 1999 ).
