Further Evaluation of the Pregnancy-Linked Down-Regulation of the Paternal Antigen-Specific Splenic Cytotoxic T Lymphocyte Activity in Allogeneically Pregnant Mice
Mahbuba Parvin
Department of Immunology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorKen-ichi Isobe
Department of Immunology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorSetsuko Goto
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorIzumi Nakashima
Department of Immunology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorYutaka Tomoda
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorMahbuba Parvin
Department of Immunology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorKen-ichi Isobe
Department of Immunology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorSetsuko Goto
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorIzumi Nakashima
Department of Immunology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorYutaka Tomoda
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Aichi, Nagoya, 466 Japan
Search for more papers by this authorAbstract
Cytotoxic T lymphocyte (CTL) activity directed against paternal alloantigen was examined in allogeneically pregnant mice using various allogeneic combinations. The spleen cells from pregnant C57BL/6 (H-2b) mice mated with BALB/c (H-2d) male mice generated less anti-H-2d CTL after in vitro sensitization than those from unpregnant or syngeneically mated C57BL/6 mice. Different allogeneic combinations including the incompatibility at only D region of H-2 or minor histocompatibility loci were effective for downregulating the anti-paternal CTL activity in pregnancy. The downregulation of anti-paternal CTL activity induced by allogeneic pregnancy occurred at day 10 to day 18 of pregnancy, most extensively at day 14. The allogeneic pregnancy also downregulated the allogeneic CTL activities that had been amplified by injecting alloantigens before mating.
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