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Carcinoembryonic Antigen in Amniotic Fluid

HÅkan Gadler

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Britta Wahren,

Britta Wahren

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Jan Lindsten,

Jan Lindsten

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Katarina Bremme,

Katarina Bremme

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Eva Malmqvist,

Eva Malmqvist

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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HÅkan Gadler,

HÅkan Gadler

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Britta Wahren,

Britta Wahren

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Jan Lindsten,

Jan Lindsten

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Katarina Bremme,

Katarina Bremme

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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Eva Malmqvist,

Eva Malmqvist

the Department of Virology, National Bacteriological Laboratory, and the Departments of Clinical Genetics, Obstetrics and Gynaecology, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden

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First published: January/December 1977

https://doi.org/10.1111/j.0954-6820.1977.tb15723.x

Citations: 10

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Abstract

ABSTRACT Carcinoembryonic antigen (CEA), a substance which is known to occur in high amounts in the fetal gut and also in certain tumors of the gastrointestinal tract, has been demonstrated in amniotic fluids from different stages of pregnancy. Radioimmunoassays of CEA in amniotic fluids of 91 normal pregnancies showed a decrease from a mean of 53 ng/ml at 19 weeks to 25 ng/ml at the end of gestation. The CEA activity in amniotic fluid was eluted in the same volume as a standard ¹²⁵I-CEA on a Sephadex G200 column. Amniotic fluid therefore contains CEA similar in molecular weight to the CEA purified from liver metastases of colonic cancer. Among 17 cases of abnormal pregnancies, CEA elevations were observed in five with anomalous fetuses.

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Volume201, Issue1-6

January/December 1977

Pages 411-413

Carcinoembryonic Antigen in Amniotic Fluid

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Carcinoembryonic Antigen in Amniotic Fluid

Abstract

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