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TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS
Peter D. Keightley,
Michael Lynch,
Peter D. Keightley
University of Edinburgh, Institute of Cell, Animal and Population Biology, West Mains Road, Edinburgh EH9 3JT, United Kingdom E-mail: [email protected]
Search for more papers by this authorMichael Lynch
Indiana University, Department of Biology, Bloomington, Indiana 47405 E-mail: [email protected]
Search for more papers by this authorPeter D. Keightley,
Michael Lynch,
Peter D. Keightley
University of Edinburgh, Institute of Cell, Animal and Population Biology, West Mains Road, Edinburgh EH9 3JT, United Kingdom E-mail: [email protected]
Search for more papers by this authorMichael Lynch
Indiana University, Department of Biology, Bloomington, Indiana 47405 E-mail: [email protected]
Search for more papers by this authorAbstract
Abstract Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.
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