Volume 45, Issue 1 pp. 85-89

Functional MRI and Wada Determination of Language Lateralization: A Case of Crossed Dominance

Michele L. Ries

Michele L. Ries

St. Jude Children's Research Hospital, Memphis, Tennessee, Arkansas Children's Hospital Little Rock, Arkansas

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Frederick A. Boop

Frederick A. Boop

St. Jude Children's Research Hospital, Memphis, Tennessee, Arkansas Children's Hospital Little Rock, Arkansas

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May L. Griebel

May L. Griebel

The University of Arkansas for Medical Sciences, Little Rock, Arkansas

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Ping Zou

Ping Zou

St. Jude Children's Research Hospital, Memphis, Tennessee, Arkansas Children's Hospital Little Rock, Arkansas

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Nicholas S. Phillips

Nicholas S. Phillips

St. Jude Children's Research Hospital, Memphis, Tennessee, Arkansas Children's Hospital Little Rock, Arkansas

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Sterling C. Johnson

Sterling C. Johnson

University of Wisconsin Medical School, Madison, Wisconsin, U.S.A.

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Jane P. Williams

Jane P. Williams

The University of Arkansas for Medical Sciences, Little Rock, Arkansas

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Kathleen J. Helton

Kathleen J. Helton

St. Jude Children's Research Hospital, Memphis, Tennessee, Arkansas Children's Hospital Little Rock, Arkansas

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Robert J. Ogg

Robert J. Ogg

St. Jude Children's Research Hospital, Memphis, Tennessee, Arkansas Children's Hospital Little Rock, Arkansas

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First published: 24 December 2003
Citations: 42
Address correspondence and reprint requests to Dr. R. J. Ogg at Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 501 St. Jude Place, Memphis, TN 38105, U.S.A. E-mail: [email protected]

Abstract

Summary:  The Wada test has historically been the conventional procedure for determining language lateralization before neurosurgery. However, functional magnetic resonance imaging (fMRI) offers a less invasive alternative to the Wada procedure. Research indicates that the two techniques used together may provide comparable, and sometimes complementary, information that results in improved prediction of postsurgical language ability. We present a case in which use of fMRI in conjunction with Wada testing provided complementary information about language lateralization before neurosurgical resection of a mesial temporal subependymoma for seizure control in a patient with schizencephaly.

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