Negative pressure wound therapy (NPWT) is a popular treatment to heal infected wounds. This meta-analysis aimed to determine if NPWT was more effective than conventional wound dressings for surgical site infections (SSI) in varied orthopaedic surgeries. Literature was retrieved from seven electronic databases (Medline, Web of Science, PubMed, Embase, Google Scholar, Cochrane Library, and CNKI). Randomised control trials (RCT) and retrospective cohort studies (RS) involving arthroplasty, fracture, and spinal surgery were extracted. SSI was our primary outcome, while total complications and length of hospital stay were secondary outcomes. We carried out the risk of bias assessment and meta-analysis using the Cochrane Risk of Bias 2.0 tool and Stata 17.0. Among the 798 studies retrieved, 18 of them met our inclusion criteria. We identified 13 RCTs and 5 RSs. The results of meta-analysis showed that the incidence of SSI in the NPWT group was significantly lower relative to the control group (OR = 0.60, 95% CI 0.47 to 0.77, P < 0.001). Subgroup analyses revealed that the incidences of SSI involving arthroplasty, fracture, and spinal surgery in the NPWT group accounted for 46%, 69%, and 37% relative to the control group, respectively. The incidence of SSI in RS (OR = 0.27, 95% CI 0.13 to 0.56) was significantly lower than that in RCT (OR = 0.69, 95% CI 0.54 to 0.90) (P = 0.02). Moreover, patients in the NPWT group had a lower total complication rate (OR = 0.51, 95% CI 0.34 to 0.76) and shorter hospital stays (SMD = −0.42, 95% CI −0.83 to −0.02), although high heterogeneity existed. NPWT may be an efficient alternative to help prevent the incidence of SSI and total complications as well as achieved shorten hospital stay in varied orthopaedic surgeries. The rational use of NPWT should be based on the presence of patients' clinical conditions and relevant risk factors.

1 INTRODUCTION

Surgical site infections (SSI) usually cause prolonged hospital stay, readmission, reoperation, and deep prosthetic infections, which not only places a significantly heavy burden on the healthcare system, but also results in substantial morbidity and decreased quality of life.¹ Patients with SSI have worse clinical outcomes, like continued pain and slow recovery of function, than otherwsie.² Patients' basic conditions and operation parameters (for example, surgery type and duration) are well-established risk factors for wound infections in orthopaedic surgery.³ As Patel et al. put it, each day of prolonged wound drainage was associated with a 29% increase in postoperative infection, even higher in obese patients.⁴

Negative pressure wound therapy (NPWT) has been reported to reduce wound complications including dehiscence, infection, hematoma and seroma.⁵ The combination of the negative pressure and the foam alters the wound environment, making inflammation modulated, excessive fluid drained, and angiogenesis promoted.⁵ NPWT was recommended to reduce infection risk and accelerate recovery in patients with cardiothoracic, abdominal, and orthopaedic surgeries.^6-9 One of the previous studies conducted a meta-analysis to compare the application of NPWT with standard care in open trauma patients, revealing no significant difference in the proportion of wounds healed at 6 weeks follow-up.¹⁰ Another meta-analysis pooled six original studies involving the comparison of NPWT with traditional wound dressings in orthopaedic trauma surgery, discovering lower incidence of deep SSI, superficial SSI, and wound dehiscence.¹¹ However, the evidence about the efficacy of NPWT for decreasing the incidence of SSI in varied orthopaedic surgeries is lacking.

The present study aimed to perform a systematic review and meta-analysis to determine whether NPWT is more effective in reducing incidence of SSI, total complication rate, and length of hospital stay after those surgeries involving arthroplasty, fracture and spinal.

2 METHODS

2.1 Registration

This study is registered on the platform of PROSPERO (CRD42020180714).

2.2 Selection criteria

We identified literature that met the following inclusion criteria: (1) Types of studies: clinical studies comparing NPWT versus conventional wound dressings for closed incisions in orthopaedic surgeries, including randomised control trials (RCT) and retrospective cohort studies (RS); (2) Types of participants: adult patients who underwent arthroplasty, fracture, and spinal surgery; (3) Studies published in English and Chinese; (4) Studies reporting the outcomes, including the incidence of SSI; and (5) full-text studies available.

The exclusion criteria were listed as follows: (1) Literature types: abstracts, letters, editorials, conference articles, case reports, reviews, animal studies, and study protocols; (2) Studies that failed to provide a direct comparison between NPWT and conventional wound dressings, or the comparative results impossible to be deduced indirectly from the published results; and (3) Repetitive studies and data.

2.3 Search methods

Two independent reviewers performed a literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Seven electronic databases (Medline, Web of Science, PubMed, Embase, Google Scholar, Cochrane Library, and CNKI) were searched from the inception of these databases to August 1, 2022. The following free terms and MeSH terms were used, such as “NPWT”, “fracture”, “orthopaedic trauma”, “arthroplasty”, “spinal surgery”, and “surgical site infections”. All the retrieved literature were scrutinised further, including the title, abstract, and full text to ensure that the selected literature fully met the inclusion criteria.

2.4 Criteria of grouping and associated definitions

Following the well-accepted practice of previous studies,^12-16 the NPWT group was recognised as a medical practice of using an open-cell solid foam or gauze laid onto the wound followed by an adherent sealed dressing. In this progress, a sealed tube was connected from the dressing to a suction pump, creating a partial vacuum over the wound. NPWT mainly adopted low negative pressure (generally 55 mmHg-175 mmHg). All hospitals used a sterile dressing sealed from external contamination. The details of the materials used were again left to the discretion of the healthcare team as per routine care at their centres.

2.5 Data analysis

In this study, meta-analysis of the included literature was implemented with Stata 17.0. Odds ratio (OR) and the standardised mean difference (SMD) were adopted, and the 95% confidence interval (CI) was used to describe dichotomous variables and continuous variables. When P < .05, it was considered that there was a statistically significant difference between the experimental group and the control group. The I² quantitative test was used to evaluate the heterogeneity of meta-analysis results. An I² < 50% suggests low heterogeneity in the meta-analysis results, then a fixed-effect model can be applied; an I² ≥ 50% indicates high heterogeneity in the meta-analysis results; then, a random-effect model can be selected; and an I² > 75% suggests obvious heterogeneity in the meta-analysis results. At this time, the sources of heterogeneity need to be carefully examined through sensitivity analysis. A funnel plot and Egger's test were adopted to examine possible publication bias. When publication bias occurred, the trim and fill analysis was applied to further evaluate the stability and reliability of the results. Finally, we performed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to clarify the overall certainty of evidence.¹⁷

2.6 Quality evaluation

Two investigators (Yuan and Chen) independently assessed the risk of bias using the Cochrane Risk of Bias 2.0 tool; any disagreement concerning the quality evaluation was resolved by discussion and consensus.¹⁸ The Cochrane Risk of Bias tool includes five specific domains: the randomisation process, deviations from intended interventions, missing outcome data, measurement of the outcome, and selection of the reported results. The tool provides an overall rating of a study, and the measured results can be classified into low-risk bias, high-risk bias, or unclear risk of bias according to prescribed judging criteria.

3 RESULTS

3.1 Descriptive statistics

A total of 798 records were identified from the above-mentioned databases. Among them, 525 studies remained after duplicate records and those marked ineligible by automated tools were removed. Forty nine studies remained further after title and abstract screening. Finally, 18 studies were screened for quantitative synthesis and meta-analysis after checked with the selection criteria (Figure 1). It is noteworthy that no restrictions were placed on the types of clinical trial design.

Details are in the caption following the image — **FIGURE 1**
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Flow diagram of study selection

3.2 Quality evaluation

As suggested by the results of the bias risk assessment, five bias areas were evaluated, including the randomisation process, deviation from expected interventions, missing outcome data, outcome measurement, and the selection of reported outcomes. Figure S1 and Figure 2 show that 10 RCTs are confirmed with a low risk of bias, while the remaining eight RCTs are classified with some concerns. The domain highly rated with some concerns was the randomisation process. Ten randomised controlled trials had clear randomization schemes. The patients were well informed of the treatment.

3.3 Characteristics of included literature

The characteristics of the included studies were shown in Table 1. A total of 5525 patients were involved, including 2467 patients in the NPWT group and 2092 patients in the control group (conventional wound dressings). Five of all the studies were retrospective studies,^19-24 and the other 13 were RCTs.^{12-16, 24-31}

TABLE 1. Descriptive characteristics of included studies

Study	Total patients (n)	Study Design	Groups size		Age, mean (SD)		BMI, mean (SD)		Male, No. (%)		Duration of NPWT treatment	Follow-up
Study	Total patients (n)	Study Design	NPWT group (n)	Comparison group (n)	NPWT group (n)	Comparison group (n)	NPWT group (n)	Comparison group (n)	NPWT group (n)	Comparison group (n)	Duration of NPWT treatment	Follow-up
Stannard et al. 2012	249	RCT	130	119	43		-	-	84 (65)	77 (65)	59 h	NR
Gillespie et al. 2015	70	RCT (2013–2014)	35	35	63.8 (14.0)	62.5 (12.4)	29.9 (5.7)	29.8 (5.3)	20 (57)	17 (49)	5 days	6 weeks
Karlakki et al. 2016	209	RCT (2012–2013)	102	107	69.0 (9.0)	69.2 (9.0)	30.1 (5.0)	28.4 (4.6)	49 (48)	55 (51)	7 days	6 weeks
Manoharan et al. 2016	33	RCT (2014)	21	36	66		29.79		19 (58)	-	8 days	NR
Cooper and Bas. 2016	138	RS (2021–2015)	30	108	71.7	70.9	31.3	29.6	-	-	9.2 days	90 days
Redfern et al. 2017	596	RCT (2013–2014)	196	400	66.9 (10.2)	66.8 (10.8)	30.5 (5.5)	30.9 (5.0)	67 (34)	184 (46)	7 days	6 weeks
Crist et al. 2017	66	RCT (2008–2012)	33	33	44.2	43.2	29.9	31	27 (82)	20 (61)	>2 days	NR
Newman et al. 2018	159	RCT	79	80	65 (11)	65 (11)	31.9 (7.5)	33.4 (7.5)	40 (51)	45 (56)	2 days	12 weeks
Cooper et al. 2018	57	RS (2010–2016)	27	40	76.3	73.2	27.3	29.9	-	-	7 days	90 days
Dingemans et al. 2018	100	RS (2000–2016)	53	47	43.9 (15.6)	42.2 (14.6)	24.4	24.7	39 (74)	36 (77)	7 days	2–4 weeks
Costa et al. 2018	460	RCT (2012–2015)	226	234	46.1 (19.9)	44.5 (19.0)	46.4	47	178 (79)	164 (70)	NR	1 year
Keeney et al. 2019	398	RCT (2014–2017)	185	213	60.6	60.5	34.6	36.5	-	-	7–35 days	2 years
Costa et al. 2020	1519	RCT (2016–2018)	770	749	49.8 (20.3)		26.4 (5.9)	26.7 (6.0)	482 (62)	482 (63)	NR	90 days
Naylor et al. 2020	469	RS (2015–2018)	76	393	58.1 (13.5)	60.8 (12.6)	29.0 (6.1)	29.4 (6.5)	-	-	5 days	NR
Masters et al.2021	432	RCT	214	218	85.2	84.9	-	-	66 (31)	59 (27)	NR	120 days
Higuera-Rueda et al. 2021	242	RCT (2017–2019)	124	118	64.7 (9.5)	65.1 (8.5)	34.7 (6.7)	34.2 (7.2)	98 (40)	-	5 days	90 days
Cooper et al. 2022	294	RCT (2018–2019)	147	147	64.9		-	-	119 (40)	-	NR	NR
Wang et al. 2022	34	RS (2012–2020)	19	15	55.2 (14.4)	54.3 (15.4)	24.3 (3.4)	25.0 (3.2)	9 (47)	8 (53)	NR	90 days

Abbreviations: LOS, length of stay; NPWT, negative pressure wound therapy; NR, no reported; RCT, randomised controlled trial; RS, retrospective study.

4 DESCRIPTION OF RESULTS

4.1 The incidence of SSI

The forest plots synthesised all the data involving SSI, of which 110 of 2467 patients were found with SSI in the NPWT group and 218 of 3092 patients in the control group. The incidence of SSI in the NPWT group was significantly lower than that in the control group (OR = 0.60, 95% CI 0.47-0.77, P < 0.001) (Figure 3). Subgroup analyses were conducted according to study design and operation site. The incidence of SSI in the NPWT group after arthroplasty was 46% relative to the control group (95% CI 0.27 to 0.79), followed by fracture (OR = 0.69, 95% CI 0.52-0.91), and spinal surgery (OR = 0.37, 95% CI 0.12-1.12). There was no significant difference by operation site (P = 0.29) (Figure 4). Furthermore, RS (OR = 0.27, 95% CI 0.13-0.56) achieved a better result than RCT (OR = 0.69, 95% CI 0.54 to 0.90). A significant difference was found by study design (P = 0.02) (Figure 5).

4.2 Total complications

Total complications were reported in 13 studies, with 2156 patients found in the NPWT group and 2485 patients in the control group. 35.95% of the patients in the NPWT group underwent complications, and 38.75% in the control group. The total complication rate in the NPWT group was significantly lower relative to the control group (OR = 0.51, 95% CI 0.34-0.76), although high heterogeneity existed (Figure 6).

4.3 Length of hospital stay (LOS)

Length of hospital stay was reported in seven studies, comprising 559 patients in the NPWT group and 777 patients in the control group. The average LOS of 4.20 and 5.06 days were found in the NPWT group and the control group, respectively. As shown in Figure 7, LOS in the NPWT group was shorter relative to the control group, although high heterogeneity existed (SMD = −0.42, 95% CI −0.83 to −0.02).

4.4 Publication bias

Publication bias was assessed by a funnel plot and Egger's test (Figure 8 and Figure S2). Although the P value was found to be 0.033 (Figure S3), the trim and fill analysis recognised these results stable (Figure S4).

4.5 Evidence grading

Primary and secondary outcomes in this meta-analysis were evaluated using the GRADE system (Table S1). The evidence quality of SSI, total complications was high, moderate, and low, respectively. We demonstrated that the overall evidence quality is moderate, which means that further research is likely to significantly change confidence in the effect estimate and may change the estimate.

5 DISCUSSION

The successful application of NPWT in healing wounds in general has led some doctors to apply NPWT to orthopaedic surgical wound dressing. This study set out a meta-analysis to compare the incidence of SSI in varied orthopaedic surgeries between NWPT and conventional wound dressing. It is found that the incidence of SSI is lower in patients in the NPWT group relative to the control group. Subgroup analyses were conducted to evaluate the change of incidence of SSI in different study designs and operation sites. Moreover, we found a lower total complication rate and shorter length of hospital stay in the NPWT group.

Previous studies have shown that reducing surgical site infection in NPWT is biologically feasible.³² Proposed mechanisms of NPWT could achieve wound shrinkage, clean extracellular fluid, and induction of cellular stretch, which are supposed to accelerate wound healing, thus creating a favourable healing environment for angiogenesis.³³ In addition，it may also serve as a microbial barrier that helps to increase blood flow and improve tissue oxygenation. In open wounds, NPWT contributes to wound healing through clearing excess interstitial fluid, reducing edema, and promoting tissue growth.³⁴

The findings of this study were consistent with previous meta-analyses. Five studies from 2018 to 2021 show with strong evidence that NPWT can significantly reduce the incidence of SSI in orthopaedic surgery wounds, whether the wounds are deep or shallow.^35-39 Furthermore, NPWT promotes not only rapid healing of open fracture wounds,³⁵ but also be effective in cases of wound dehiscence.^{10, 37} Some studies also evaluate other outcomes, such as mortality, reoperation, incidence of seroma, pain, quality of life scores, and so forth.^{38, 39} However, it is reported that NPWT significantly increased the medical cost of patients undergoing elective primary hip arthroplasty.¹³

This is a comprehensive meta-analysis to evaluate the incidence of SSI between NPWT and traditional wound dressings in varied orthopaedic surgeries and compare relevant efficacies among different operation sites. We also assessed data from both randomised trials and observational studies, applying the GRADE approach to appraise the available evidence. However, very few studies have demonstrated any economic benefits of NPWT application in varied orthopaedic surgeries. In addition, long-term use of NPWT may bring in added values, like accelerating the final reconstruction of muscle and fasciocutaneous flap recovery. Therefore, more evidence is welcome to prove the feasibility and effectiveness of NPWT in this field.

This meta-analysis has some limitations. First, despite that most of the included studies had a scientific and rigorous experimental design, high patient compliance, low follow-up losses, and high quality, the above-mentioned factors also contributed a lot to the unclear risk of bias, thus accounting for high heterogeneity in the meta-analysis results as well. Secondly, the injury severity and treatment protocol of these studies varied, and not all studies reported the details. Third, the patients in the studies received NPWT at different durations and frequencies. Therefore, high-quality RCTs with a larger sample size and standard protocol should be incorporated in future studies to examine the role of NPWT for the incidence of SSI, length of hospital stay as well as comprehensive medical cost.

To sum up, NPWT may be a safe and effective way to accelerate wound healing in arthroplasty, fracture, and spinal surgery. The rational use of NPWT should be based on the presence of patients' clinical conditions and relevant risk factors.

AUTHOR CONTRIBUTIONS

All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. YS designed the study. YS and DL acquired the study data. HF and ZZ analysed and interpreted the data. YS wrote the first draft of the manuscript. All authors revised the manuscript and approved it for publication.

FUNDING INFORMATION

Sichuan Provincial Science and Technology Plan, Grant#: 2018JY0324.

CONFLICT OF INTEREST

All authors have no conflict of interest to report for this study.

ETHICAL APPROVAL

Ethical approval was waived for this meta-analysis because it only involves published patient data.

Open Research

DATA AVAILABILITY STATEMENT

Data sharing not applicable to this article as no datasets were generated or analysed during the current study

Supporting Information

REFERENCES

1Alverdy JC, Hyman N, Gilbert J. Re-examining causes of surgical site infections following elective surgery in the era of asepsis. Lancet Infect Dis. 2020; 20(3): e38-e43.
10.1016/S1473-3099(19)30756-X
CAS PubMed Web of Science® Google Scholar
2Zhou J, Wang R, Huo X, Xiong W, Kang L, Xue Y. Incidence of surgical site infection after spine surgery: a systematic review and meta-analysis. Spine. 2020; 45(3): 208-216.
10.1097/BRS.0000000000003218
PubMed Web of Science® Google Scholar
3Shao J, Zhang H, Yin B, Li J, Zhu Y, Zhang Y. Risk factors for surgical site infection following operative treatment of ankle fractures: a systematic review and meta-analysis. Int J Surg. 2018; 56: 124-132.
10.1016/j.ijsu.2018.06.018
PubMed Web of Science® Google Scholar
4Patel VP, Walsh M, Sehgal B, Preston C, DeWal H, Di Cesare PE. Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty. J Bone Joint Surg Am. 2007; 89(1): 33-38.
10.2106/00004623-200701000-00005
PubMed Web of Science® Google Scholar
5Huang C, Leavitt T, Bayer LR, Orgill DP. Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 2014; 51(7): 301-331.
10.1067/j.cpsurg.2014.04.001
PubMed Web of Science® Google Scholar
6Colli A, Camara ML. First experience with a new negative pressure incision management system on surgical incisions after cardiac surgery in high risk patients. J Cardiothorac Surg. 2011; 6: 160.
10.1186/1749-8090-6-160
PubMed Web of Science® Google Scholar
7Stannard JP, Gabriel A, Lehner B. Use of negative pressure wound therapy over clean, closed surgical incisions. Int Wound J. 2012; 9 Suppl 1(Suppl 1): 32-39.
10.1111/j.1742-481X.2012.01017.x
Web of Science® Google Scholar
8Suzuki T, Minehara A, Matsuura T, Kawamura T, Soma K. Negative-pressure wound therapy over surgically closed wounds in open fractures. J Orthop Surg. 2014; 22(1): 30-34.
10.1177/230949901402200109
Web of Science® Google Scholar
9Hudson DA, Adams KG, Van Huyssteen A, Martin R, Huddleston EM. Simplified negative pressure wound therapy: clinical evaluation of an ultraportable, no-canister system. Int Wound J. 2015; 12(2): 195-201.
10.1111/iwj.12080
PubMed Web of Science® Google Scholar
10Iheozor-Ejiofor Z, Newton K, Dumville JC, Costa ML, Norman G, Bruce J. Negative pressure wound therapy for open traumatic wounds. Cochrane Database Syst Rev. 2018; 7(7): CD012522.
PubMed Web of Science® Google Scholar
11Wang C, Zhang Y, Qu H. Negative pressure wound therapy for closed incisions in orthopedic trauma surgery: a meta-analysis. J Orthop Surg Res. 2019; 14(1): 427.
10.1186/s13018-019-1488-z
PubMed Web of Science® Google Scholar
12Stannard JP, Volgas DA, McGwin G 3rd, et al. Incisional negative pressure wound therapy after high-risk lower extremity fractures. J Orthop Trauma. 2012; 26(1): 37-42.
10.1097/BOT.0b013e318216b1e5
PubMed Web of Science® Google Scholar
13Gillespie BM, Rickard CM, Thalib L, et al. Use of negative-pressure wound dressings to prevent surgical site complications after primary hip arthroplasty: a pilot RCT. Surg Innov. 2015; 22(5): 488-495.
10.1177/1553350615573583
PubMed Web of Science® Google Scholar
14Karlakki SL, Hamad AK, Whittall C, Graham NM, Banerjee RD, Kuiper JH. Incisional negative pressure wound therapy dressings (iNPWTd) in routine primary hip and knee arthroplasties: a randomised controlled trial. Bone Joint Res. 2016; 5(8): 328-337.
10.1302/2046-3758.58.BJR-2016-0022.R1
CAS PubMed Web of Science® Google Scholar
15Manoharan V, Grant AL, Harris AC, Hazratwala K, Wilkinson MP, McEwen PJ. Closed incision negative pressure wound therapy vs conventional dry dressings after primary knee arthroplasty: a randomized controlled study. J Arthroplasty. 2016; 31(11): 2487-2494.
10.1016/j.arth.2016.04.016
PubMed Web of Science® Google Scholar
16Redfern RE, Cameron-Ruetz C, O'Drobinak SK, Chen JT, Beer KJ. Closed incision negative pressure therapy effects on postoperative infection and surgical site complication after Total hip and knee arthroplasty. J Arthroplasty. 2017; 32(11): 3333-3339.
10.1016/j.arth.2017.06.019
PubMed Web of Science® Google Scholar
17Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008; 336(7650): 924-926.
10.1136/bmj.39489.470347.AD
PubMed Web of Science® Google Scholar
18Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366:l4898.
10.1136/bmj.l4898
PubMed Google Scholar
19Cooper HJ, Bas MA. Closed-incision negative-pressure therapy versus antimicrobial dressings after revision hip and knee surgery: a comparative study. J Arthroplasty. 2016; 31(5): 1047-1052.
10.1016/j.arth.2015.11.010
PubMed Web of Science® Google Scholar
20Naylor RM, Gilder HE, Gupta N, et al. Effects of negative pressure wound therapy on wound dehiscence and surgical site infection following instrumented spinal fusion surgery-a single Surgeon's experience. World Neurosurg. 2020; 137: e257-e262.
10.1016/j.wneu.2020.01.152
PubMed Web of Science® Google Scholar
21Wang J, Yang Y, Xing W, Xing H, Bai Y, Chang Z. Safety and efficacy of negative pressure wound therapy in treating deep surgical site infection after lumbar surgery. Int Orthop. 2022; 46(11): 2629-2635.
10.1007/s00264-022-05531-w
PubMed Web of Science® Google Scholar
22Dingemans SA, Birnie MFN, Backes M, et al. Prophylactic negative pressure wound therapy after lower extremity fracture surgery: a pilot study. Int Orthop. 2018; 42(4): 747-753.
10.1007/s00264-018-3781-6
PubMed Web of Science® Google Scholar
23Cooper HJ, Roc GC, Bas MA, et al. Closed incision negative pressure therapy decreases complications after periprosthetic fracture surgery around the hip and knee. Injury. 2018; 49(2): 386-391.
10.1016/j.injury.2017.11.010
PubMed Web of Science® Google Scholar
24Crist BD, Oladeji LO, Khazzam M, Della Rocca GJ, Murtha YM, Stannard JP. Role of acute negative pressure wound therapy over primarily closed surgical incisions in acetabular fracture ORIF: a prospective randomized trial. Injury. 2017; 48(7): 1518-1521.
10.1016/j.injury.2017.04.055
PubMed Web of Science® Google Scholar
25Newman JM, Siqueira MBP, Klika AK, Molloy RM, Barsoum WK, Higuera CA. Use of closed incisional negative pressure wound therapy after revision Total hip and knee arthroplasty in patients at high risk for infection: a prospective, randomized clinical trial. J Arthroplasty. 2019; 34(3): 554-559.e1.
10.1016/j.arth.2018.11.017
PubMed Web of Science® Google Scholar
26Costa ML, Achten J, Bruce J, et al. Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb: the WOLLF randomized clinical trial. JAMA. 2018; 319(22): 2280-2288.
10.1001/jama.2018.6452
PubMed Web of Science® Google Scholar
27Keeney JA, Cook JL, Clawson SW, Aggarwal A, Stannard JP. Incisional negative pressure wound therapy devices improve short-term wound complications, but not long-term infection rate following hip and knee arthroplasty. J Arthroplasty. 2019; 34(4): 723-728.
10.1016/j.arth.2018.12.008
PubMed Web of Science® Google Scholar
28Costa ML, Achten J, Knight R, et al. Effect of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma: the WHIST randomized clinical trial. JAMA. 2020; 323(6): 519-526.
10.1001/jama.2020.0059
PubMed Web of Science® Google Scholar
29Higuera-Rueda CA, Emara AK, Nieves-Malloure Y, et al. The effectiveness of closed-incision negative-pressure therapy versus silver-impregnated dressings in mitigating surgical site complications in high-risk patients after revision knee arthroplasty: the PROMISES randomized controlled trial. J Arthroplasty. 2021; 36(7 S): S295-S302.e14.
10.1016/j.arth.2021.02.076
PubMed Web of Science® Google Scholar
30Masters J, Cook J, Achten J, Costa ML, WHISH Study Group. A feasibility study of standard dressings versus negative-pressure wound therapy in the treatment of adult patients having surgical incisions for hip fractures: the WHISH randomized controlled trial. Bone Joint J. 2021; 103-B(4): 755-761.
10.1302/0301-620X.103B4.BJJ-2020-1603.R1
PubMed Web of Science® Google Scholar
31Cooper HJ, Bongards C, Silverman RP. Cost-effectiveness of closed incision negative pressure therapy for surgical site management after revision Total knee arthroplasty: secondary analysis of a randomized clinical trial. J Arthroplasty. 2022; 37(8 S): S790-S795.
10.1016/j.arth.2022.03.022
PubMed Web of Science® Google Scholar
32Nolff MC, Meyer-Lindenberg A. Vakuumassistierte Wundbehandlung (negative pressure wound therapy, NPWT) in der Kleintiermedizin. Wirkweise, Anwendung und Indikationen [negative pressure wound therapy (NPWT) in small animal medicine. Mechanisms of action, applications and indications]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2016; 44(1): 26-38.
10.15654/TPK-150957
CAS PubMed Web of Science® Google Scholar
33Namgoong S, Han SK. Status of wound management in Korea. Wound Repair Regen. 2018; 26(Suppl 1): S3-S8.
10.1111/wrr.12576
PubMed Google Scholar
34Normandin S, Safran T, Winocour S, et al. Negative pressure wound therapy: mechanism of action and clinical applications. Semin Plast Surg. 2021; 35(3): 164-170.
10.1055/s-0041-1731792
PubMed Web of Science® Google Scholar
35Liu X, Zhang H, Cen S, Huang F. Negative pressure wound therapy versus conventional wound dressings in treatment of open fractures: a systematic review and meta-analysis. Int J Surg. 2018; 53: 72-79.
10.1016/j.ijsu.2018.02.064
PubMed Web of Science® Google Scholar
36Gao J, Wang Y, Song J, Li Z, Ren J, Wang P. Negative pressure wound therapy for surgical site infections: a systematic review and meta-analysis. J Adv Nurs. 2021; 77(10): 3980-3990.
10.1111/jan.14876
PubMed Web of Science® Google Scholar
37Grant-Freemantle MC, Ryan ÉJ, Flynn SO, et al. The effectiveness of negative pressure wound therapy versus conventional dressing in the treatment of open fractures: a systematic review and meta-analysis. J Orthop Trauma. 2020; 34(5): 223-230.
10.1097/BOT.0000000000001750
PubMed Web of Science® Google Scholar
38Norman G, Goh EL, Dumville JC, et al. Negative pressure wound therapy for surgical wounds healing by primary closure. Cochrane Database Syst Rev. 2020; 6(6): CD009261.
PubMed Google Scholar
39Kuo FC, Hsu CW, Tan TL, Lin PY, Tu YK, Chen PC. Effectiveness of different wound dressings in the reduction of blisters and periprosthetic joint infection after Total joint arthroplasty: a systematic review and network meta-analysis. J Arthroplasty. 2021; 36(7): 2612-2629.
10.1016/j.arth.2021.02.047
PubMed Web of Science® Google Scholar

Citing Literature

Volume20, Issue6

August 2023

Pages 2334-2345

Filename	Description
iwj14043-sup-0001-FigureS1.tiffTIFF image, 1.1 MB	Figure S1. Risk of bias graph
iwj14043-sup-0002-FigureS2.tiffTIFF image, 44.1 KB	Figure S2. Egger's test of included studies
iwj14043-sup-0003-FigureS3.tiffTIFF image, 12.3 KB	Figure S3. Egger's test (continued)
iwj14043-sup-0004-FigureS4.tiffTIFF image, 13 KB	Figure S4. Trim and fill analysis
iwj14043-sup-0005-Table S1.docxWord 2007 document , 15.7 KB	Table S1. GRADE assessment

RETRACTED: Impact of negative pressure wound treatment on incidence of surgical site infection in varied orthopedic surgeries: A systematic review and meta-analysis

Retraction(s) for this article

RETRACTION: Impact of Negative Pressure Wound Treatment on Incidence of Surgical Site Infection in Varied Orthopedic Surgeries: A Systematic Review and Meta-Analysis

Abstract

1 INTRODUCTION