INVITED REVIEW
Microbial orchestra in juvenile idiopathic arthritis: Sounds of disarray?
Miika Arvonen,
Petri Vänni,
Aditya Narayan Sarangi,
Mysore V Tejesvi,
Paula Vähäsalo,
Amita Aggarwal,
Matthew L Stoll,
Miika Arvonen
Department of Pediatrics, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Search for more papers by this authorPetri Vänni
PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Genobiomics LLC, Oulu, Finland
Search for more papers by this authorAditya Narayan Sarangi
Biomedical Informatics Center, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for more papers by this authorMysore V Tejesvi
Department of Ecology and Genetics, University of Oulu, Oulu, Finland
Genobiomics LLC, Oulu, Finland
Search for more papers by this authorPaula Vähäsalo
PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
Medical Research Center Oulu, Oulu, Finland
Search for more papers by this authorAmita Aggarwal
Department of Clinical Immunology & Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for more papers by this authorCorresponding Author
Matthew L Stoll
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Correspondence
Matthew L Stoll, From the Department of Pediatrics at the University of Alabama at Birmingham, Birmingham, Alabama, USA.
Email: [email protected]
Search for more papers by this authorMiika Arvonen,
Petri Vänni,
Aditya Narayan Sarangi,
Mysore V Tejesvi,
Paula Vähäsalo,
Amita Aggarwal,
Matthew L Stoll,
Miika Arvonen
Department of Pediatrics, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Search for more papers by this authorPetri Vänni
PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Genobiomics LLC, Oulu, Finland
Search for more papers by this authorAditya Narayan Sarangi
Biomedical Informatics Center, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for more papers by this authorMysore V Tejesvi
Department of Ecology and Genetics, University of Oulu, Oulu, Finland
Genobiomics LLC, Oulu, Finland
Search for more papers by this authorPaula Vähäsalo
PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
Medical Research Center Oulu, Oulu, Finland
Search for more papers by this authorAmita Aggarwal
Department of Clinical Immunology & Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Search for more papers by this authorCorresponding Author
Matthew L Stoll
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Correspondence
Matthew L Stoll, From the Department of Pediatrics at the University of Alabama at Birmingham, Birmingham, Alabama, USA.
Email: [email protected]
Search for more papers by this authorThis article is part of a series of reviews covering Inflammatory Arthritis appearing in Volume 294 of Immunological Reviews.
Abstract
The role of the microbiota in multiple autoimmune diseases, including juvenile idiopathic arthritis (JIA) has earned substantial attention in the last 10 years. Increasing evidence suggests that the microbiota's link to JIA begins in early childhood, as early life events that influence the nature of the microbiota also appear to influence disease risk. In this review, we discuss these early life events including mode of delivery, infant feeding practice, antibiotics exposure, and other events and their impacts on the microbiota and on disease risk; reported abnormalities of the microbiota in children with JIA; mechanisms by which an altered microbiota at birth and later on in childhood may influence disease risk; and the prospects for therapeutic alteration of the microbiota in children with JIA.
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