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Cellular metabolism modulation in T lymphocyte immunity

Huanrong Liu

Huanrong Liu

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

Department Liver Surgery and Liver Transplantation, Shanghai Jiao-tong University School of Medicine Renji Hospital, Shanghai, China

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Hui Yang

Hui Yang

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

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Xi Chen

Xi Chen

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

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Yun Lu

Yun Lu

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

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Zhengguo Zhang

Zhengguo Zhang

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

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Jian Wang

Jian Wang

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

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Ming Zhang

Ming Zhang

Department Liver Surgery and Liver Transplantation, Shanghai Jiao-tong University School of Medicine Renji Hospital, Shanghai, China

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Lixiang Xue

Corresponding Author

Lixiang Xue

Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China

Corresponding Authors:

Dr. Guangwei Liu, Fudan University, Yixueyuan Road 138, Xuhui District, Shanghai, China 200032; Phone: (86) 21-54237563; Fax: (86) 21-54237563; Email: [email protected];

Dr. Feng Xue, Shanghai Jiao-tong University School of Medicine Renji Hospital, Dong-fang Road 1630, Shanghai, China 200127; Phone: (86)21- 68383754; Fax: (86)21- 58737232; E-mail: [email protected];

Dr. Lixiang Xue, Peking University, Xueruan Road 38, Haidian District, Beijing, China 100191; Phone: (86)10-82802527; Fax: (86) 10-82802527; Email: [email protected];

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Feng Xue

Corresponding Author

Feng Xue

Department Liver Surgery and Liver Transplantation, Shanghai Jiao-tong University School of Medicine Renji Hospital, Shanghai, China

Corresponding Authors:

Dr. Guangwei Liu, Fudan University, Yixueyuan Road 138, Xuhui District, Shanghai, China 200032; Phone: (86) 21-54237563; Fax: (86) 21-54237563; Email: [email protected];

Dr. Feng Xue, Shanghai Jiao-tong University School of Medicine Renji Hospital, Dong-fang Road 1630, Shanghai, China 200127; Phone: (86)21- 68383754; Fax: (86)21- 58737232; E-mail: [email protected];

Dr. Lixiang Xue, Peking University, Xueruan Road 38, Haidian District, Beijing, China 100191; Phone: (86)10-82802527; Fax: (86) 10-82802527; Email: [email protected];

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Guangwei Liu

Corresponding Author

Guangwei Liu

Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences

Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China

Corresponding Authors:

Dr. Guangwei Liu, Fudan University, Yixueyuan Road 138, Xuhui District, Shanghai, China 200032; Phone: (86) 21-54237563; Fax: (86) 21-54237563; Email: [email protected];

Dr. Feng Xue, Shanghai Jiao-tong University School of Medicine Renji Hospital, Dong-fang Road 1630, Shanghai, China 200127; Phone: (86)21- 68383754; Fax: (86)21- 58737232; E-mail: [email protected];

Dr. Lixiang Xue, Peking University, Xueruan Road 38, Haidian District, Beijing, China 100191; Phone: (86)10-82802527; Fax: (86) 10-82802527; Email: [email protected];

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First published: 19 May 2014
Citations: 12

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1111/imm.12321

Abstract

T lymphocytes are a central component, and play an important role in controlling immunity and immunological diseases. Recent studies have shown that T cell metabolism is highly dynamic and has a tremendous impact on the modulation of T lymphocyte immunity. Specific metabolic pathways meet energy and biosynthetic requirements that can support specific T cell functional activities in immunity and immunological diseases. This review summarizes the recent progresses about the modulatory role of cell metabolism in T cell development, differentiation, activation and function in immunity. These might provide new opportunities to modulate the immune responses and treat clinical immunological diseases.

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