Review
Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema
Jilin Bai,
Patrick D. Lyden,
Jilin Bai
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Search for more papers by this authorCorresponding Author
Patrick D. Lyden
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Correspondence: Patrick D. Lyden, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
E-mail: [email protected]
Search for more papers by this authorJilin Bai,
Patrick D. Lyden,
Jilin Bai
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Search for more papers by this authorCorresponding Author
Patrick D. Lyden
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Correspondence: Patrick D. Lyden, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
E-mail: [email protected]
Search for more papers by this authorConflict of interest: None declared.
Abstract
Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic thrombolysis for acute ischemic stroke. To understand the paradox of injury caused by treatment, we first emphasize the phenomenon in which recanalization of an occluded artery does not lead to tissue reperfusion. Additionally, no-reflow after recanalization may be due to injury of the neurovascular unit, distal microthrombosis, or both, and certainly worsens outcome. We examine the mechanism of molecular and subcellular damage in the neurovascular unit, notably oxidative stress, mitochondrial dysfunction, and apoptosis. At the level of the neurovascular unit, which mediates crosstalk between the damaged brain and systemic responses in blood, we summarize emerging evidence demonstrating that individual cell components play unique and cumulative roles that lead to damage of the blood–brain barrier and neurons. Furthermore, we review the latest developments in establishing a link between the immune system and microvascular dysfunction during ischemic reperfusion. Progress in assessing reperfusion injury has also been made, and we review imaging studies using various magnetic resonance imaging modalities. Lastly, we explore potential treatment approaches, including ischemic preconditioning, postconditioning, pharmacologic agents, and hypothermia.
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