Association of gut microbiome with fasting triglycerides, fasting insulin and obesity status in Mexican children
Miguel Vazquez-Moreno
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Search for more papers by this authorAleyda Perez-Herrera
Consejo Nacional de Ciencia y Tecnología, Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional, Unidad Oaxaca, Oaxaca, Mexico
Search for more papers by this authorDaniel Locia-Morales
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Search for more papers by this authorSara Dizzel
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Search for more papers by this authorDavid Meyre
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Search for more papers by this authorCorresponding Author
Jennifer C. Stearns
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Correspondence
Miguel Cruz, Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc, 330 C.P. 06725, México City, Mexico.
Email: [email protected]
Jennifer C. Stearns, McMaster University, Health Sciences Center, Room 3N6, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Miguel Cruz
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Correspondence
Miguel Cruz, Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc, 330 C.P. 06725, México City, Mexico.
Email: [email protected]
Jennifer C. Stearns, McMaster University, Health Sciences Center, Room 3N6, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada.
Email: [email protected]
Search for more papers by this authorMiguel Vazquez-Moreno
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Search for more papers by this authorAleyda Perez-Herrera
Consejo Nacional de Ciencia y Tecnología, Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional, Unidad Oaxaca, Oaxaca, Mexico
Search for more papers by this authorDaniel Locia-Morales
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Search for more papers by this authorSara Dizzel
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Search for more papers by this authorDavid Meyre
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Search for more papers by this authorCorresponding Author
Jennifer C. Stearns
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Correspondence
Miguel Cruz, Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc, 330 C.P. 06725, México City, Mexico.
Email: [email protected]
Jennifer C. Stearns, McMaster University, Health Sciences Center, Room 3N6, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Miguel Cruz
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Correspondence
Miguel Cruz, Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc, 330 C.P. 06725, México City, Mexico.
Email: [email protected]
Jennifer C. Stearns, McMaster University, Health Sciences Center, Room 3N6, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada.
Email: [email protected]
Search for more papers by this authorFunding information: Instituto Mexicano del Seguro Social, Grant/Award Number: FIS/IMSS/PROT/PRIO/17/062
Summary
Background
The association of gut microbiota with obesity and its cardio-metabolic complications in paediatric populations is still controversial.
Objective
We investigated the association of obesity and cardio-metabolic traits with gut microbiota on 167 and 163 children with normal weight and obesity from Mexico City and Oaxaca, Mexico.
Methods
Anthropometric and biochemical traits were measured. The microbial communities were determined by high-throughput sequencing of bacterial 16S rRNA gene v3-v4 region.
Results
The gut microbial community structure was associated with obesity and fasting plasma insulin (FPI) in Mexico City (PObesity = 0.012, PFPI = 0.0003) and Oaxaca (PObesity = 0.034, PFPI = 0.016), and with triglycerides (TG) in Oaxaca (P = .0002). The Firmicutes/Bacteroidetes ratio was positively associated with TG in Oaxaca (P = .003). Firmicutes and Bacteroidetes phyla were positively and negatively associated with obesity (Mexico City: PFirmicutes = 0.013, PBacteroidetes = 0.009) and TG (Oaxaca: PFirmicutes = 0.002, PBacteroidetes = 0.004). In Oaxaca, Verrucomicrobia was negatively associated with obesity (P = .004). In Mexico City, the bacterial genus Fusicatenibacter, Romboutsia, Ruminococcaceae, Ruminiclostridium, Blautia, Clostridium, Anaerostipes and Intestinibacter were associated with obesity and FPI, while in Oaxaca, Bacteroides, Alistipes and Clostridium were associated with TG.
Conclusion
The gut microbial community structure in children is associated with obesity and FPI in Mexico City, and with obesity, FPI and TG in Oaxaca.
CONFLICT OF INTEREST
The authors declare no conflicts of interest.
Supporting Information
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| ijpo12748-sup-0001-Supinfo.pdfPDF document, 786.6 KB | Data S1. Supporting Information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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