Crimean-Congo haemorrhagic fever-induced liver injury: A systematic review and meta-analysis
Corresponding Author
Sawai Singh Rathore
Internal Medicine, Dr. Sampurnanand Medical College, Jodhpur, India
Correspondence
Sawai Singh Rathore, Internal Medicine, Dr. Sampurnanand Medical College, Residency Road, Shastri Nagar, Jodhpur 342003, India.
Email: [email protected]
Search for more papers by this authorAde Harrison Manju
Clinical Pathology, Faculty of Biochemical Science, University of Yaounde I, Yaounde, Cameroon
Search for more papers by this authorQingqing Wen
Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA
Search for more papers by this authorManush Sondhi
Internal Medicine, Kasturba Medical College, Manipal, India
Search for more papers by this authorReshma Pydi
Internal Medicine, Andhra Medical College, Visakhapatnam, India
Search for more papers by this authorMuhammad Adnan Ali
Internal Medicine, Jinnah Sindh Medical University, Karachi, Pakistan
Search for more papers by this authorSohaib Tousif
Internal Medicine, Ziauddin Medical University, Karachi, Pakistan
Search for more papers by this authorRomil Singh
Department of Critical Care, Mayo Clinic, Rochester, Minnesota, USA
Search for more papers by this authorAbdul-Azeez Muhammed
Internal Medicine, Federal Medical Center, Katsina, Nigeria
Search for more papers by this authorNoman Khurshid Ahmed
Internal Medicine, Dow Medical College, Karachi, Pakistan
Search for more papers by this authorDeep Manojkumar Patel
Our Lady of Fatima University College of Medicine, Valenzuela City, Philippines
Search for more papers by this authorCorresponding Author
Sawai Singh Rathore
Internal Medicine, Dr. Sampurnanand Medical College, Jodhpur, India
Correspondence
Sawai Singh Rathore, Internal Medicine, Dr. Sampurnanand Medical College, Residency Road, Shastri Nagar, Jodhpur 342003, India.
Email: [email protected]
Search for more papers by this authorAde Harrison Manju
Clinical Pathology, Faculty of Biochemical Science, University of Yaounde I, Yaounde, Cameroon
Search for more papers by this authorQingqing Wen
Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA
Search for more papers by this authorManush Sondhi
Internal Medicine, Kasturba Medical College, Manipal, India
Search for more papers by this authorReshma Pydi
Internal Medicine, Andhra Medical College, Visakhapatnam, India
Search for more papers by this authorMuhammad Adnan Ali
Internal Medicine, Jinnah Sindh Medical University, Karachi, Pakistan
Search for more papers by this authorSohaib Tousif
Internal Medicine, Ziauddin Medical University, Karachi, Pakistan
Search for more papers by this authorRomil Singh
Department of Critical Care, Mayo Clinic, Rochester, Minnesota, USA
Search for more papers by this authorAbdul-Azeez Muhammed
Internal Medicine, Federal Medical Center, Katsina, Nigeria
Search for more papers by this authorNoman Khurshid Ahmed
Internal Medicine, Dow Medical College, Karachi, Pakistan
Search for more papers by this authorDeep Manojkumar Patel
Our Lady of Fatima University College of Medicine, Valenzuela City, Philippines
Search for more papers by this authorAbstract
Background
Crimean-Congo haemorrhagic fever (CCHF) is a fatal acute tick-borne viral infection and substantial emerging global public health threat. This illness has a high case fatality rate of up to 40%. The liver is one of the important target organs of the CCHF virus.
Objective
The aim of this meta-analysis to evaluate the correlation between CCHF and liver injury and draw more generalised inferences about the abnormal serum markers of liver injury such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) in CCHF patients.
Methods
A literature search was accomplished for published eligible articles with MEDLINE/PubMed and Embase databases. All eligible observational studies and case series were included from around the world. The inclusion criteria were articles describing liver injury biomarkers amongst patients diagnosed with CCHF.
Results
Data from 18 studies, consisting of 1238 patients with CCHF were included in this meta-analysis. Overall pooled incidence of at least one raised liver injury biomarker was 77.95% (95% CI, I2 = 88.50%, P < .0001). Similarly, pooled incidence of elevated AST and ALT was 85.92% (95% CI, I2 = 85.27%, P < .0001) and 64.30% (95% CI, I2 = 88.32%, P < .0001), respectively. Both Egger and Begg-Mazumdar's tests detected no apparent publication bias in all three meta-analyses (P > .05).
Conclusion
Our study shows that CCHF has a very detrimental effect on liver function. Abnormal liver function may lead to poor prognosis and increased morbidity and mortality in CCHF patients. Hence, Physicians must recognise and continuously monitor these biomarkers, since these markers may aid in early stratification of prognosis and the prevention of severe outcomes in infection with such a high case fatality rate.
CONFLICTS OF INTEREST
The authors have no potential conflicts of interest to disclose.
Supporting Information
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| ijcp14775-sup-0001-TableS1.docxapplication/docx, 9 KB | Table S1 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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