Volume 44, Issue 14 pp. E346-E352

Original Article

Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma

Chinbold Enkhbold,

Chinbold Enkhbold

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Tohru Utsunomiya,

Tohru Utsunomiya

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Yuji Morine,

Yuji Morine

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Satoru Imura,

Satoru Imura

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Tetsuya Ikemoto,

Tetsuya Ikemoto

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Yusuke Arakawa,

Yusuke Arakawa

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Mami Kanamoto,

Mami Kanamoto

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Shuichi Iwahashi,

Shuichi Iwahashi

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Yu Saito,

Yu Saito

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Daichi Ishikawa,

Daichi Ishikawa

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Mitsuo Shimada,

Corresponding Author

Mitsuo Shimada

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

Correspondence: Professor Mitsuo Shimada, Department of Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. Email: [email protected]Search for more papers by this author

Chinbold Enkhbold,

Chinbold Enkhbold

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Tohru Utsunomiya,

Tohru Utsunomiya

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Yuji Morine,

Yuji Morine

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Satoru Imura,

Satoru Imura

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Tetsuya Ikemoto,

Tetsuya Ikemoto

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Yusuke Arakawa,

Yusuke Arakawa

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Mami Kanamoto,

Mami Kanamoto

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Shuichi Iwahashi,

Shuichi Iwahashi

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Yu Saito,

Yu Saito

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Daichi Ishikawa,

Daichi Ishikawa

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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Mitsuo Shimada,

Corresponding Author

Mitsuo Shimada

Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

First published: 19 February 2014

https://doi.org/10.1111/hepr.12314

Citations: 23

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Abstract

Aim

FBXW7 acts as a tumor suppressor gene by targeting several oncogenic regulators of proliferation, growth and apoptosis for proteasomal degradation. However, the significance of this protein is not yet well understood in intrahepatic cholangiocarcinoma (IHCC). In this study, we aimed to investigate the correlation between FBXW7 expression and clinicopathological variables in IHCC patients.

Methods

Thirty-one patients with IHCC who underwent hepatic resection were enrolled. FBXW7 expression in tumor tissue was determined by immunohistochemistry and patients were divided into two groups, the FBXW7 high expression group (n = 11) and the FBXW7 low expression group (n = 20). We then compared clinicopathological variables including prognosis between the high and low expression groups in tumor tissue.

Results

FBXW7 expression was significantly correlated with staging (P = 0.006), and tended to correlate with lymph node metastasis. The FBXW7 low expression group had significantly poorer prognosis compared with the FBXW7 high expression group (P = 0.020); 3-year survival rates were 29.4% and 72.7%, respectively. Furthermore, the disease-free survival rate in the FBXW7 low expression group was significantly worse than in the FBXW7 high expression group (P = 0.022). On multivariate analysis, intrahepatic metastasis (P = 0.006) was a significant independent prognostic factor for disease-free survival, and FBXW7 low expression tended to be an independent prognostic factor for both overall (P = 0.067) and disease-free survival (P = 0.083).

Conclusion

Our results confirmed that low expression of FBXW7 in IHCC correlates with tumor progression and poor prognosis in IHCC.

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Volume44, Issue14

December 2014

Pages E346-E352

Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma

Abstract

Aim

Methods

Results

Conclusion

References

Citing Literature

References

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Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma

Abstract

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Conclusion

References

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