New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study
Lu Lu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorWeixi Xiong
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorDan Liu
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJing Liu
Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China
Search for more papers by this authorDan Yang
Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China
Search for more papers by this authorNian Li
Department of Medical Affairs, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJie Mu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJian Guo
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorWeimin Li
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorGang Wang
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorHui Gao
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorYingying Zhang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorMintao Lin
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorLei Chen
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorSisi Shen
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorHesheng Zhang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJosemir W. Sander
National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London Queen Square Institute of Neurology, London, UK
Chalfont Centre for Epilepsy, Chalfont St Peter, UK
Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands
Search for more papers by this authorCorresponding Author
Jianfei Luo
Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China
Correspondence
Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Email: [email protected]
Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Email: [email protected]
Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Shengli Chen
Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China
Correspondence
Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Email: [email protected]
Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Email: [email protected]
Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dong Zhou
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Email: [email protected]
Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Email: [email protected]
Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Email: [email protected]
Search for more papers by this authorLu Lu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorWeixi Xiong
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorDan Liu
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJing Liu
Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China
Search for more papers by this authorDan Yang
Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China
Search for more papers by this authorNian Li
Department of Medical Affairs, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJie Mu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJian Guo
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorWeimin Li
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorGang Wang
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorHui Gao
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorYingying Zhang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorMintao Lin
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorLei Chen
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorSisi Shen
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorHesheng Zhang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorJosemir W. Sander
National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London Queen Square Institute of Neurology, London, UK
Chalfont Centre for Epilepsy, Chalfont St Peter, UK
Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands
Search for more papers by this authorCorresponding Author
Jianfei Luo
Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China
Correspondence
Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Email: [email protected]
Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Email: [email protected]
Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Shengli Chen
Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China
Correspondence
Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Email: [email protected]
Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Email: [email protected]
Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dong Zhou
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Email: [email protected]
Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Email: [email protected]
Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Email: [email protected]
Search for more papers by this authorAbstract
Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID-19). This multicenter retrospective study enrolled people with COVID-19 from January 18 to February 18, 2020 at 42 government-designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had a severe condition. None in this cohort had a known history of epilepsy. Neither acute symptomatic seizures nor status epilepticus was observed. Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. There was no evidence suggesting an additional risk of acute symptomatic seizures in people with COVID-19. Neither the virus nor potential risk factors for seizures seem to be significant risks for the occurrence of acute symptomatic seizures in COVID-19.
CONFLICT OF INTEREST
None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
Supporting Information
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