Volume 61, Issue 6 pp. e49-e53
BRIEF COMMUNICATION

New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study

Lu Lu

Lu Lu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Weixi Xiong

Weixi Xiong

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Dan Liu

Dan Liu

Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China

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Jing Liu

Jing Liu

Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China

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Dan Yang

Dan Yang

Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China

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Nian Li

Nian Li

Department of Medical Affairs, West China Hospital, Sichuan University, Chengdu, China

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Jie Mu

Jie Mu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Jian Guo

Jian Guo

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Weimin Li

Weimin Li

Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China

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Gang Wang

Gang Wang

Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China

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Hui Gao

Hui Gao

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Yingying Zhang

Yingying Zhang

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Mintao Lin

Mintao Lin

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Lei Chen

Lei Chen

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Sisi Shen

Sisi Shen

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Hesheng Zhang

Hesheng Zhang

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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Josemir W. Sander

Josemir W. Sander

National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London Queen Square Institute of Neurology, London, UK

Chalfont Centre for Epilepsy, Chalfont St Peter, UK

Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands

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Jianfei Luo

Corresponding Author

Jianfei Luo

Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China

Correspondence

Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.

Email: [email protected]

Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

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Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.

Email: [email protected]

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Shengli Chen

Corresponding Author

Shengli Chen

Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China

Correspondence

Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.

Email: [email protected]

Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Email: [email protected]

Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.

Email: [email protected]

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Dong Zhou

Corresponding Author

Dong Zhou

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

Correspondence

Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.

Email: [email protected]

Jianfei Luo, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Email: [email protected]

Shengli Chen, Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing, China.

Email: [email protected]

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First published: 18 April 2020
Citations: 219
Authors Lu Lu, Weixi Xiong, and Dan Liu contributed equally to the work.

Abstract

Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID-19). This multicenter retrospective study enrolled people with COVID-19 from January 18 to February 18, 2020 at 42 government-designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had a severe condition. None in this cohort had a known history of epilepsy. Neither acute symptomatic seizures nor status epilepticus was observed. Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. There was no evidence suggesting an additional risk of acute symptomatic seizures in people with COVID-19. Neither the virus nor potential risk factors for seizures seem to be significant risks for the occurrence of acute symptomatic seizures in COVID-19.

CONFLICT OF INTEREST

None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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