Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment
J. Lee
Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Search for more papers by this authorS. W. Seo
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea
Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea
Search for more papers by this authorJ.-J. Yang
Department of Biomedical Engineering, Hanyang University, Seoul, Korea
Search for more papers by this authorY. K. Jang
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Search for more papers by this authorJ. S. Lee
Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea
Search for more papers by this authorY. J. Kim
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Gangwon-do, Korea
Search for more papers by this authorJ. Chin
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Search for more papers by this authorJ. M. Lee
Department of Biomedical Engineering, Hanyang University, Seoul, Korea
Search for more papers by this authorS. T. Kim
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorK.-H. Lee
Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorJ. H. Lee
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Search for more papers by this authorJ. S. Kim
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Search for more papers by this authorS. Kim
Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorH. Yoo
Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorA. Y. Lee
Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
Search for more papers by this authorD. L. Na
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea
Search for more papers by this authorCorresponding Author
H. J. Kim
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Correspondence: H. J. Kim, Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 80 Ilwon-ro, Gangnam-gu, Seoul 06351, Korea (tel.: +82 2 2148 9794; fax: +82 2 3410 0052; e-mail: [email protected]).Search for more papers by this authorJ. Lee
Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Search for more papers by this authorS. W. Seo
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea
Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea
Search for more papers by this authorJ.-J. Yang
Department of Biomedical Engineering, Hanyang University, Seoul, Korea
Search for more papers by this authorY. K. Jang
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Search for more papers by this authorJ. S. Lee
Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea
Search for more papers by this authorY. J. Kim
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Gangwon-do, Korea
Search for more papers by this authorJ. Chin
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Search for more papers by this authorJ. M. Lee
Department of Biomedical Engineering, Hanyang University, Seoul, Korea
Search for more papers by this authorS. T. Kim
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorK.-H. Lee
Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorJ. H. Lee
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Search for more papers by this authorJ. S. Kim
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Search for more papers by this authorS. Kim
Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorH. Yoo
Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorA. Y. Lee
Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
Search for more papers by this authorD. L. Na
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea
Search for more papers by this authorCorresponding Author
H. J. Kim
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Neuroscience Center, Samsung Medical Center, Seoul, Korea
Correspondence: H. J. Kim, Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 80 Ilwon-ro, Gangnam-gu, Seoul 06351, Korea (tel.: +82 2 2148 9794; fax: +82 2 3410 0052; e-mail: [email protected]).Search for more papers by this authorAbstract
Background and purpose
Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.
Methods
Seventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [11C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.
Results
There was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI.
Conclusions
We suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI.
Supporting Information
| Filename | Description |
|---|---|
| ene13500-sup-0001-FigS1-S2.docxWord document, 602.6 KB | Figure S1. Regions showing more rapid cortical thinning in late stage svMCI compared to early stage svMCI independent of PiB SUVR or lacune number over 3 years Figure S2. Cortical thinning regions related to baseline disease stage |
| ene13500-sup-0002-SupInfo.docxWord document, 630.7 KB |
Data S1. Detailed methods of PiB acquisition and data analysis Data S2. Image processing for cortical thickness measurement Table S1. Mixed effect models analyzing the rate of cognitive decline in total, ES-svMCI and LS-svMCI Table S2. Mixed effect models analyzing the rate of cognitive decline in svMCI as functions of baseline CDR-SOB by time |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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