Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease
Corresponding Author
Angelo Zinellu
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Correspondence to: Dr Angelo Zinellu, Department Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. Tel.: +39 079229775; fax: +39 079228275; e-mail: [email protected]Search for more papers by this authorAlessandro Giuseppe Fois
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorSalvatore Sotgia
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Search for more papers by this authorElisabetta Zinellu
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorFabiana Bifulco
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorGianfranco Pintus
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Search for more papers by this authorArduino A. Mangoni
Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, SA, Australia
Search for more papers by this authorCiriaco Carru
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Search for more papers by this authorPietro Pirina
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorCorresponding Author
Angelo Zinellu
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Correspondence to: Dr Angelo Zinellu, Department Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. Tel.: +39 079229775; fax: +39 079228275; e-mail: [email protected]Search for more papers by this authorAlessandro Giuseppe Fois
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorSalvatore Sotgia
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Search for more papers by this authorElisabetta Zinellu
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorFabiana Bifulco
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorGianfranco Pintus
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Search for more papers by this authorArduino A. Mangoni
Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, SA, Australia
Search for more papers by this authorCiriaco Carru
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Search for more papers by this authorPietro Pirina
Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
Search for more papers by this authorAbstract
Chronic obstructive pulmonary disease (COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress (OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers (TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and lung function tests were measured in patients with mild stable asthma (n = 24) and mild stable COPD (n = 29) and in age- and sex-matched controls. Forced expiratory volume in 1 s (FEV1) was associated with age both in patients and control groups. By contrast, FEV1 was positively correlated with PSH only in COPD (ρ = 0·49, P = 0·007). In multiple logistic regression analysis, lower PSH was the only OS marker independently associated with increased odds of both asthma (OR = 0·32, 95% CI 0·13–0·78, P = 0·01) and COPD (OR = 0·50, 95% CI 0·26–0·95, P = 0·03). These findings suggest that proteins -SH are a sensitive OS marker in early COPD and asthma.
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