Volume 42, Issue 5 e70133

ORIGINAL ARTICLE

Strain Measures of Atrial and Ventricular Diastolic Function in Pediatric Fontan Patients: Comparisons to Controls and Between Ventricular Morphology Types

Robert W. Loar,

Corresponding Author

Robert W. Loar

[email protected]

orcid.org/0000-0002-3859-1294

Pediatric Cardiology, Cook Children's Medical Center, Fort Worth, Texas, USA

Department of Pediatrics, Burnett School Medicine at TCU, Fort Worth, Texas, USA

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Ricardo H. Pignatelli,

Ricardo H. Pignatelli

Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA

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J. Christopher Wilkinson,

J. Christopher Wilkinson

Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA

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Christopher R. Broda,

Christopher R. Broda

Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA

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John L. Colquitt,

John L. Colquitt

Pediatric Cardiology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA

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Robert W. Loar,

Corresponding Author

Robert W. Loar

[email protected]

orcid.org/0000-0002-3859-1294

Pediatric Cardiology, Cook Children's Medical Center, Fort Worth, Texas, USA

Department of Pediatrics, Burnett School Medicine at TCU, Fort Worth, Texas, USA

Search for more papers by this author

Ricardo H. Pignatelli,

Ricardo H. Pignatelli

Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA

Search for more papers by this author

J. Christopher Wilkinson,

J. Christopher Wilkinson

Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA

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Christopher R. Broda,

Christopher R. Broda

Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA

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John L. Colquitt,

John L. Colquitt

Pediatric Cardiology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA

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First published: 26 April 2025

https://doi.org/10.1111/echo.70133

Citations: 1

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ABSTRACT

Background

Fontan patients may have abnormal diastolic function, but this is poorly characterized using conventional echocardiography. Herein, we describe atrial function and other diastolic strain measurements in a cohort of pediatric Fontan patients, with comparisons to healthy controls and between right ventricle (RV) and left ventricle (LV) types.

Methods

This is a single-institution, cross-sectional study of healthy controls (n = 50) and patients with a Fontan circulation (n = 50, 29 RV type, 21 LV type). Parameters of atrial function and ventricular systolic and diastolic function derived from speckle-tracking echocardiography (STE) were retrospectively obtained from apical four-chamber images. These included three phases of atrial strain (Ɛ) and strain rate (SR): contraction (ac), conduit (con), and reservoir (res), and diastolic SR for passive (E-SR) and active (A-SR) filling.

Results

Fontan patients had lower Ɛcon (13.4% vs. 28.2%, p < 0.01) and Ɛres (22.8% vs. 37.7%, p < 0.01) compared to controls. They had a longer time to peak atrial filling (450 ms vs. 399 ms, p < 0.01) and a greater reliance on atrial contraction for ventricular filling (atrial contraction fraction 41% vs. 26%, p < 0.01). RV type Fontan patients had longer time to peak atrial filling (461 ms vs. 406 ms, p = 0.02) and lower E-SR (1.0 %/s vs. 1.4%/s, p = 0.01) compared to LV type.

Conclusions

Several atrial and diastolic strain parameters in pediatric Fontan patients are altered compared to controls. Additionally, some metrics are more deranged in RV type Fontan patients. This highlights the need for population-specific normal values in patients with a Fontan circulation. Study of the clinical correlations and prognostic value of these STE-derived parameters is also warranted.

Open Research

Data Availability Statement

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

Supporting Information

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Citing Literature

Volume42, Issue5

May 2025

e70133

Strain Measures of Atrial and Ventricular Diastolic Function in Pediatric Fontan Patients: Comparisons to Controls and Between Ventricular Morphology Types

ABSTRACT

Background

Methods

Results

Conclusions

Open Research

Data Availability Statement

Supporting Information

References

Citing Literature

References

Information

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Strain Measures of Atrial and Ventricular Diastolic Function in Pediatric Fontan Patients: Comparisons to Controls and Between Ventricular Morphology Types

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Routine Echocardiographic Assessments of Single Ventricle Patients Should Include Atrial Strain

ABSTRACT

Background

Methods

Results

Conclusions

Open Research

Data Availability Statement

Supporting Information

References

Citing Literature

References

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