Left ventricular endocardial longitudinal dysfunction persists after acute myocarditis with preserved ejection fraction
Corresponding Author
Gianluca Di Bella PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Correspondence
Gianluca Di Bella, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Email: [email protected]
Search for more papers by this authorScipione Carerj MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorAntonino Recupero MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorRocco Donato PhD
Department of Radiological Science, University of Messina, Messina, Italy
Search for more papers by this authorPietro Pugliatti PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorGabriella Falanga PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorGiampiero Vizzari MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorMariapaola Campisi MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorConcetta Zito PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorCesare de Gregorio MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorCorresponding Author
Gianluca Di Bella PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Correspondence
Gianluca Di Bella, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Email: [email protected]
Search for more papers by this authorScipione Carerj MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorAntonino Recupero MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorRocco Donato PhD
Department of Radiological Science, University of Messina, Messina, Italy
Search for more papers by this authorPietro Pugliatti PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorGabriella Falanga PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorGiampiero Vizzari MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorMariapaola Campisi MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorConcetta Zito PhD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorCesare de Gregorio MD
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Search for more papers by this authorAbstract
Background
The aim of present study was to assess left ventricular (LV) myocardial deformation and changes over time in patients with acute myocarditis (AM) with preserved ejection fraction detected by late gadolinium enhancement (LGE) magnetic resonance imaging.
Methods
Thirty-five male patients with AM diagnoses and preserved systolic function based on cardiac magnetic resonance imaging (MRI) were prospectively enrolled. On admission, echocardiography with measurements of global and segmental longitudinal (LS) strains was performed both at the endocardial (ENDO) and epicardial (EPI) levels. Findings were compared to 25 control subjects. Twenty-six patients were also monitored over a 22-month follow-up (FU group).
Results
On admission, global ENDO-LS was poorer in magnitude in AM (−19.2 ± 3.1) than in controls (−24.0 ± 1.05) (P < 0.0001), whereas EPI-LS was not different (−20.6 ± 3.4 vs −19.7 ± 6 P = NS). A functional increase in magnitude in both ENDO-LS (−20.8 ± 5.4, P = NS) and EPI-LS (−22.6 ± 4.6, P = 0.02) was found in FU vs AM patients.
Conclusions
The present study demonstrates a steady ENDO-LS impairment in infarct-like AM during a 2-year follow-up period, despite a preserved LV ejection fraction.
CONFLICT OF INTEREST
On behalf of all authors, the corresponding author states that there is no conflict of interest.
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