The benefit of a ceramide-linoleic acid-containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses
Qi Yang
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorMin Liu
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorCorresponding Author
Xia Li
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Correspondence
Xia Li, Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197, Rui Jin Er Road, Shanghai 200025, China.
Email: [email protected]
Search for more papers by this authorJie Zheng
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorQi Yang
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorMin Liu
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorCorresponding Author
Xia Li
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Correspondence
Xia Li, Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197, Rui Jin Er Road, Shanghai 200025, China.
Email: [email protected]
Search for more papers by this authorJie Zheng
Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorFunding information: National Natural Science Foundation of China, Grant/Award Numbers: 81673056, 81830095
Abstract
Atopic dermatitis (AD), chronic eczema, and pruritus hiemalis are a set of prevalent chronic xerotic skin disorders that share clinical features such as dryness, scales, and pruritus. A ceramide deficiency and defective epidermal functions are common in these diseases. This study was designed to assess the effect of ceramide-linoleic acid (LA-Cer)–containing moisturizer as an adjunctive therapy in the treatment of AD, chronic eczema, and pruritus hiemalis. In a 2-month study, patients with one of these three diseases were divided into two groups. The control group was treated with mometasone furoate (0.1%) cream (MF), whereas the treatment group received 0.1% MF in combination with an LA-Cer-containing moisturizer. Capacitance and transepidermal water loss were measured in normal and lesional skin, along with Eczema Assessment Severity Index and pruritus scores at Weeks 0, 2, 4, and 8. The results showed that tropical applications of an LA-Cer-containing moisturizer in combination with a topical glucocorticoid accelerated the reestablishment of epidermal permeability barrier and the amelioration of pruritus in patients with AD and pruritus hiemalis. However, it did not provide the same effect for chronic eczema. Thus, the efficacy of this combination therapy for this set of xerotic disorders requires further evaluation.
CONFLICT OF INTEREST
The authors declare no potential conflict of interest.
Supporting Information
| Filename | Description |
|---|---|
| dth13017-sup-0001-Tables.docxWord 2007 document , 22.7 KB |
Table S1 Subjects Distribution Table S2. Assessments of Epidermal Biophysical Properties and Clinical Evaluation in Atopic Dermatitis Patients Treated with MF and MF Plus LA-Cer Moisturizer. Table S3. Assessments of Epidermal Biophysical Properties and Clinical Evaluation in Chronic Eczema Patients Treated with MF and MF Plus LA-Cer Moisturizer. Table S4. Assessments of Epidermal Biophysical Properties and Clinical Evaluation in Pruritus Hiemalis Patients Treated with MF and MF Plus LA-Cer Moisturizer. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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