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Pain in adults with cerebral palsy: A systematic review

First published: 03 July 2025

Pain is a commonly reported issue in adults with cerebral palsy (CP). Given its negative impact on daily life, it is crucial to understand pain development, burden, and effective treatment options.

Six databases were searched for studies published since 1990 describing pain in adults with CP. Both acute and chronic pain studies were included. Information was summarized and confidence in results reported.

Of 63 studies, 47 described pain prevalence; that is, the percentage of persons in the group studied who had pain. Prevalence ranged between 24% and 89%, increased with age, and was higher in women. In studies that asked about chronic pain, defined as pain for longer than 3 months, 75% of adults reported chronic pain.

Pain is common in adults with CP, but there is a lack of evidence about effective pain interventions because there are few studies and low confidence in results, due to methods and sample sizes. Studies investigating factors for the development of pain patterns are needed to design interventions and better inform treatment recommendations. Research is needed to assess the effectiveness of established approaches to the management of pain among adults with CP.

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