Ribose-based cross-linked scaffold for correction of alveolar ridge defects

Background

Correction of alveolar ridge defects is commonly accomplished with mineralized bone substitutes with or without barrier membranes. This approach has been successful in obtaining volumetric gains. However, residual graft material particles may negatively affect tissue quality.

Aim/Hypothesis

To evaluate the effectiveness of a ribose-based cross-linked absorbable scaffold for correction of alveolar ridge defects associated with implant sites.

Material and Methods

Twenty-four consecutive patients were treated for correction of alveolar ridge defects using a ribose-based cross-linked absorbable scaffold that was folded a either a double or triple layer for volumetric augmentation. These patients were followed for at least 12 months. CBCT images were obtained at 12 months for radiographic analysis and comparison.

Results

Successful augmentation was achieved with this approach, with stable results. No adverse reactions were observed. radiographic evaluation determined an average of 2.6 mm of buccal bone augmentation and 3.2 soft tissue thickening. These results appeared to be stable and resulted in significant aesthetic enhancement of the implant sites.

Conclusion and Clinical Implications

Based on the limitations of this clinical observation, ribose-based cross-linked absorbable scaffolds provide a promising alternative to mineralized bone substitutes for ridge augmentation at implant sites. Further studies are needed to confirm these findings.