Efficacy of alveolar ridge preservation with xenografts and resorbable socket sealing materials in the esthetic region: A systematic review with meta-analyses
Karin Apaza-Bedoya PhD
Centre for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil
Search for more papers by this authorCorresponding Author
Gabriel Leonardo Magrin PhD
Centre for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil
Department of Surgery and Medical-Surgical Specialties (Dentistry - Unit of Periodontology), Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain
Correspondence
Gabriel Leonardo Magrin, Center for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Campus Reitor João David Ferreira Lima s/n, 88040-900, Florianópolis, SC, Brazil.
Email: [email protected]
Mario Romandini, Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Mario Romandini PhD
Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
Correspondence
Gabriel Leonardo Magrin, Center for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Campus Reitor João David Ferreira Lima s/n, 88040-900, Florianópolis, SC, Brazil.
Email: [email protected]
Mario Romandini, Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Email: [email protected]
Search for more papers by this authorJuan Blanco-Carrión PhD
Department of Surgery and Medical-Surgical Specialties (Dentistry - Unit of Periodontology), Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain
Search for more papers by this authorCesar Augusto Magalhães Benfatti PhD
Centre for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil
Search for more papers by this authorKarin Apaza-Bedoya PhD
Centre for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil
Search for more papers by this authorCorresponding Author
Gabriel Leonardo Magrin PhD
Centre for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil
Department of Surgery and Medical-Surgical Specialties (Dentistry - Unit of Periodontology), Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain
Correspondence
Gabriel Leonardo Magrin, Center for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Campus Reitor João David Ferreira Lima s/n, 88040-900, Florianópolis, SC, Brazil.
Email: [email protected]
Mario Romandini, Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Mario Romandini PhD
Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
Correspondence
Gabriel Leonardo Magrin, Center for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Campus Reitor João David Ferreira Lima s/n, 88040-900, Florianópolis, SC, Brazil.
Email: [email protected]
Mario Romandini, Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Email: [email protected]
Search for more papers by this authorJuan Blanco-Carrión PhD
Department of Surgery and Medical-Surgical Specialties (Dentistry - Unit of Periodontology), Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain
Search for more papers by this authorCesar Augusto Magalhães Benfatti PhD
Centre for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil
Search for more papers by this authorAbstract
Aim
The present systematic review aimed to identify and summarize the clinical, radiographic, and histological outcomes of alveolar ridge preservation using bone xenografts and absorbable sealing materials compared with spontaneous healing in the esthetic zone.
Materials and methods
Randomized clinical trials (RCTs) fulfilling specific eligibility criteria were included. Two review authors independently searched for eligible studies, extracted data from the published reports and performed the risk of bias assessment (RoB 2 tool). Study results were summarized using random effects meta-analyses.
Results
Thirteen articles concerning 10 RCTs were included, involving a total of 357 participants. Most of studies were considered as “low” risk of bias. Meta-analyses indicated less horizontal (difference in means—MD = 1.88 mm; p < 0.001), vertical mid-buccal (MD = 1.84 mm; p < 0.001) and vertical mid-lingual (MD = 2.27 mm; p < 0.001) bone resorption in alveolar ridge preservation compared to spontaneous healing as assessed clinically. Bone changes assessed radiographically showed consistent results in terms of horizontal (at 1 mm: MD = 1.84 mm, p < 0.001), vertical mid-buccal (MD = 0.95 mm; p < 0.001) and mid-lingual (MD = 0.62 mm; p = 0.05) resorption. Part of the bone resorption in the spontaneous healing group was compensated by soft-tissues, since the observed differences between groups in linear ridge reduction evaluated through cast models superimposition were smaller (MD = 0.52 mm; p < 0.001).
Conclusions
Alveolar ridge preservation with xenogeneic bone substitutes and non-autogenous resorbable socket sealing materials is efficacious in reducing post-extraction bone and ridge changes in the esthetic region.
CONFLICT OF INTEREST STATEMENT
The authors do not have any financial interest in companies whose materials are included in this article and declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that supports the findings of this study are available in the supplementary material of this article.
Supporting Information
| Filename | Description |
|---|---|
| Supplementary File.zipZip archive, 201.5 KB | Supplementary File |
| cid13257-sup-0002-AppendixS1.docxWord 2007 document , 18.9 KB | APPENDIX S1. Database search strategy. |
| cid13257-sup-0003-AppendixS2.docxWord 2007 document , 21.1 KB | APPENDIX S2. Excluded papers with reasons for exclusion. |
| cid13257-sup-0004-TableS1.docxWord 2007 document , 64.2 KB | Table S1. Summary of descriptive characteristics of included articles (n = 13). |
| cid13257-sup-0005-TableS2.docxWord 2007 document , 37.7 KB | Table S2. GRADE assessment. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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