Concurrence of mixed cryoglobulinaemia and cold agglutinin disease, and the putative role for a stereotyped immunoglobulin light chain
Ylenia A. Minafò
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorNicola Monaco
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorValerio Fiorilli
Rheumatology, Department of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorFrancesca La Gualana
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorMatteo D'Ambrosi
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorChiara De Renzis
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorStefania Basili
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorMaurizio Sorice
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorSerelina Coluzzi
Immunohaematology and Transfusion Medicine, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
Search for more papers by this authorRoberta Priori
Saint Camillus International University of Health Science, UniCamillus, Rome, Italy
Search for more papers by this authorMarcella Visentini
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorFabrizio Conti
Rheumatology, Department of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorCorresponding Author
Milvia Casato
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Correspondence
Milvia Casato, Department of Translational and Precision Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185 Rome, Italy.
Email: [email protected]
Search for more papers by this authorYlenia A. Minafò
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorNicola Monaco
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorValerio Fiorilli
Rheumatology, Department of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorFrancesca La Gualana
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorMatteo D'Ambrosi
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorChiara De Renzis
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorStefania Basili
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorMaurizio Sorice
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorSerelina Coluzzi
Immunohaematology and Transfusion Medicine, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
Search for more papers by this authorRoberta Priori
Saint Camillus International University of Health Science, UniCamillus, Rome, Italy
Search for more papers by this authorMarcella Visentini
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorFabrizio Conti
Rheumatology, Department of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorCorresponding Author
Milvia Casato
Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Correspondence
Milvia Casato, Department of Translational and Precision Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185 Rome, Italy.
Email: [email protected]
Search for more papers by this authorYlenia A. Minafò and Nicola Monaco contributed equally to this work.
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REFERENCES
- 1Berentsen S. Cold agglutinin disease. Hematology Am Soc Hematol Educ Program. 2016; 2016(1): 226–231.
- 2Khwaja J, Vos JMI, Pluimers TE, Japzon N, Patel A, Salter S, et al. Clinical and clonal characteristics of monoclonal immunoglobulin M-associated type I cryoglobulinaemia. Br J Haematol. 2024; 204(1): 177–185.
- 3Khwaja J, Japzon N, Gabriel M, Raju K, Rajaratnam V, Gupta R, et al. Cold agglutinin disease and cryoglobulinaemia: a frequent coexistence with clinical impact. Br J Haematol. 2024; 204(2): e21–e24.
- 4De Re V, De Vita S, Gasparotto D, Marzotto A, Carbone A, Ferraccioli G, et al. Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas. Eur J Immunol. 2002; 32(3): 903–910.
- 5Barnes JL, Goñi F, Heyermann H, Frangione B, Agnello V. Human rheumatoid factor cross-idiotypes. III. Bla monoclonal rheumatoid factor, prototype of the BLA cross-idiotype group, has distinct kappa chains related to the V kappa III subgroup and VH4 heavy chains. Arthritis Rheum. 1990; 33(11): 1710–1715. https://doi.org/10.1002/art.1780331115
- 6Goñi F, Chen PP, Pons-Estel B, Carson DA, Frangione B. Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity. J Immunol. 1985; 135(6): 4073–4079. https://doi.org/10.4049/jimmunol.135.6.4073
- 7Singh M, Jackson KJL, Wang JJ, Schofield P, Field MA, Koppstein D, et al. Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody. Cell. 2020; 180(5): 878–894.
- 8Minafò YA, Del Padre M, Cristofoletti C, Caprini E, Perez M, Aranburu A, et al. A stereotyped light chain may shape virus-specific B-cell receptors in HCV-dependent lymphoproliferative disorders. Genes Immun. 2020; 21(2): 131–135.
- 9Małecka A, Trøen G, Tierens A, Østlie I, Małecki J, Randen U, et al. Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity. Haematologica. 2016; 101(9): e361–e364.
- 10Kostareli E, Gounari M, Janus A, Murray F, Brochet X, Giudicelli V, et al. Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with RF activity. Leukemia. 2012; 26(5): 1127–1131.
- 11Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol. 2002; 169(7): 3777–3782.
- 12Richardson C, Chida AS, Adlowitz D, Silver L, Fox E, Jenks SA, et al. Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus. J Immunol. 2013; 191(10): 4926–4939.
- 13Shiroishi M, Ito Y, Shimokawa K, Lee JM, Kusakabe T, Ueda T. Structure–function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity. J Biol Chem. 2018; 293(18): 7008–7016.
- 14Chen F, Tzarum N, Wilson IA, Law M. VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design. Curr Opin Virol. 2019; 34: 149–159.
- 15Barcellini W, Zaja F, Zaninoni A, Imperiali FG, Battista ML, Di Bona E, et al. Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anaemia: clinical efficacy and biological studies. Blood. 2012; 119(16): 3691–3697.
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