Research Letter
Clinical, biophysical and immunohistochemical analysis of skin reactions to acute skin barrier disruption – a comparative trial between participants with sensitive skin and those with nonsensitive skin
R.J.H. Richters,
N.E. Uzunbajakava,
D. Falcone,
J.C.M. Hendriks,
E.J. Jaspers,
P.C.M. van de Kerkhof,
P.E.J. van Erp,
Corresponding Author
R.J.H. Richters
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
E-mail: [email protected]Search for more papers by this authorN.E. Uzunbajakava
Philips Research, Philips Electronics Nederland B.V., Eindhoven, the Netherlands
Search for more papers by this authorD. Falcone
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
Search for more papers by this authorJ.C.M. Hendriks
Radboud Institute for Health Sciences (RIHS), Nijmegen, the Netherlands
Search for more papers by this authorE.J. Jaspers
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
Search for more papers by this authorP.C.M. van de Kerkhof
Radboud Institute for Health Sciences (RIHS), Nijmegen, the Netherlands
Search for more papers by this authorP.E.J. van Erp
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
Search for more papers by this authorR.J.H. Richters,
N.E. Uzunbajakava,
D. Falcone,
J.C.M. Hendriks,
E.J. Jaspers,
P.C.M. van de Kerkhof,
P.E.J. van Erp,
Corresponding Author
R.J.H. Richters
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
E-mail: [email protected]Search for more papers by this authorN.E. Uzunbajakava
Philips Research, Philips Electronics Nederland B.V., Eindhoven, the Netherlands
Search for more papers by this authorD. Falcone
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
Search for more papers by this authorJ.C.M. Hendriks
Radboud Institute for Health Sciences (RIHS), Nijmegen, the Netherlands
Search for more papers by this authorE.J. Jaspers
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
Search for more papers by this authorP.C.M. van de Kerkhof
Radboud Institute for Health Sciences (RIHS), Nijmegen, the Netherlands
Search for more papers by this authorP.E.J. van Erp
Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands
Search for more papers by this authorFunding sources: The costs made to conduct this study were paid by Philips Electronics Nederland B.V.
Conflicts of interest: N.E.U. is an employee of Philips Electronics Nederland B.V. and received a salary for this study.
Supporting Information
| Filename | Description |
|---|---|
| bjd14307-sup-0001-AppendixS1.docWord document, 288 KB | Appendix S1. Questionnaire. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1Farage MA. How do perceptions of sensitive skin differ at different anatomical sites? An Epidemiological Study Clin Exp Dermatol 2009; 34: e521–30.
- 2Guinot C, Malvy D, Mauger E et al. Self-reported skin sensitivity in a general adult population in France: data of the SU.VI.MAX cohort. J Eur Acad Dermatol Venereol 2006; 20: 380–90.
- 3Misery L, Myon E, Martin N et al. [Sensitive skin in France: an epidemiological approach]. Ann Dermatol Venereol 2005; 132: 425–9 (in French).
- 4Sparavigna A, Di Pietro A, Setaro M. ‘Healthy skin’: significance and results of an Italian study on healthy population with particular regard to ‘sensitive’ skin. Int J Cosmet Sci 2005; 27: 327–31.
- 5Willis CM, Shaw S, De Lacharrière O. et al. Sensitive skin: an epidemiological study. Br J Dermatol 2001; 145: 258–63.
- 6Misery L, Myon E, Martin N et al. Sensitive skin: psychological effects and seasonal changes. J Eur Acad Dermatol Venereol 2007; 21: 620–8.
- 7Morizot F, Guinot C, Lopez J et al. Sensitive skin: analysis of symptoms, perceived causes and possible mechanisms. Cosmet Toilet 2000; 115: 83–9.
- 8Saint-Martory C, Roguedas-Contios A.M, Sibaud V et al. Sensitive skin is not limited to the face. Br J Dermatol 2008; 158: 130–3.
- 9Diogo L, Papoila A.L. Is it possible to characterize objectively sensitive skin? Skin Res Technol 2010; 16: 30–7.
- 10Primavera G, Berardesca E. Sensitive skin: mechanisms and diagnosis. Int J Cosmet Sci 2005; 27: 1–10.
- 11Farage MA. Enhancement of visual scoring of skin irritant reactions using cross-polarized light and parallel-polarized light. Contact Dermatitis 2008; 58: 147–55.
- 12Farage MA, Katsarou A, Maibach HI. Sensory, clinical and physiological factors in sensitive skin: a review. Contact Dermatitis 2006; 55: 1–14.
- 13Farage MA, Maibach HI. Sensitive skin: closing in on a physiological cause. Contact Dermatitis 2010; 62: 137–49.
- 14Basketter DA, Griffiths HA. A study of the relationship between susceptibility to skin stinging and skin irritation. Contact Dermatitis 1993; 29: 185–8.
- 15Coverly J, Peters L, Whittle E, Basketter DA. Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship? Contact Dermatitis 1998; 38: 90–5.
- 16Lammintausta K, Maibach HI, Wilson D. Mechanisms of subjective (sensory) irritation. Propensity to non-immunologic contact urticaria and objective irritation in stingers. Derm Beruf Umwelt 1988; 36: 45–9.
- 17Marriott M, Holmes J, Peters L et al. The complex problem of sensitive skin. Contact Dermatitis 2005; 53: 93–9.
- 18Hendriks AG, Keijsers RR, Seyger MM et al. Are newly discovered drivers of immune-mediated skin disorders expressed in normal skin regenerating from standardized surface injury? Dermatology 2014; 228: 255–60.
- 19Keijsers RR, Hendriks AG, van Erp PE et al. In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORt and IL-17. J Invest Dermatol 2014; 134: 1276–84.
- 20Ota N, Kasahara T, Fujiwara N et al. Identification of skin sensitivity through corneocytes measurement. SCCJ 2002; 36: 289–96.
- 21Muizzuddin N, Marenus KD, Maes DH. Factors defining sensitive skin and its treatment. Am J Contact Dermat 1998; 9: 170–5.
- 22Sparavigna A, Pietro A, Setaro M. Sensitive skin: correlation with skin surface microrelief appearance. Skin Res Technol 2006; 12: 7–10.
- 23Fullerton A, Fischer T, Lahti A et al. Guidelines for measurement of skin colour and erythema. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis 1996; 35: 1–10.
- 24Pierard GE. EEMCO guidance for the assessment of skin colour. J Eur Acad Dermatol Venereol 1998; 10: 1–11.
- 25An S, Lee E, Kim S et al. Comparison and correlation between stinging responses to lactic acid and bioengineering parameters. Contact Dermatitis 2007; 57: 158–62.
- 26Wu Y, Wang X, Zhou Y et al. Correlation between stinging, TEWL and capacitance. Skin Res Technol 2003; 9: 90–3.
- 27Roussaki-Schulze AV, Zafiriou E, Nikoulis D et al. Objective biophysical findings in patients with sensitive skin. Drugs Exp Clin Res 2005; 31(Suppl.): 17–24.
- 28Kim E, Kim S, Nam GW et al. The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation. Int J Cosmet Sci 2009; 31: 263–9.
- 29Schliemann S, Antonov D, Manegold N, Elsner P. Sensory irritation caused by two organic solvents – short-time single application and repeated occlusive test in stingers and non-stingers. Contact Dermatitis 2011; 65: 107–14.
- 30De Jongh CM, Verberk MM, Withagen C.E et al. Stratum corneum cytokines and skin irritation response to sodium lauryl sulfate. Contact Dermatitis 2006; 54: 325–33.
- 31Pinto P, Rosado C, Parreirao C, Rodrigues LM. Is there any barrier impairment in sensitive skin?: a quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves. Skin Res Technol 2011; 17: 181–5.
- 32Distante F, Rigano L, D'Agostino BA, Berardesca ER. Intra- and inter-individual differences in sensitive skin. Cosmet Toilet 2002; 117: 39–46.
