Volume 71, Issue 3 pp. 687-695
BIOMETRIC METHODOLOGY

The proportional odds cumulative incidence model for competing risks

Frank Eriksson

Corresponding Author

Frank Eriksson

Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, Copenhagen DK-1014, Denmark

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Jianing Li

Jianing Li

Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, U.S.A.

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Thomas Scheike

Thomas Scheike

Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, Copenhagen DK-1014, Denmark

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Mei-Jie Zhang

Mei-Jie Zhang

Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, U.S.A.

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First published: 26 May 2015
Citations: 30

Summary

We suggest an estimator for the proportional odds cumulative incidence model for competing risks data. The key advantage of this model is that the regression parameters have the simple and useful odds ratio interpretation. The model has been considered by many authors, but it is rarely used in practice due to the lack of reliable estimation procedures. We suggest such procedures and show that their performance improve considerably on existing methods. We also suggest a goodness-of-fit test for the proportional odds assumption. We derive the large sample properties and provide estimators of the asymptotic variance. The method is illustrated by an application in a bone marrow transplant study and the finite-sample properties are assessed by simulations.

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