Positivity of high-sensitivity HBsAg test, not previous HBV infection, indicates poor prognosis in patients with non-HBV-related HCC
This article relates to:
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Letter: Positivity of High-Sensitivity HBsAg Test Was Significantly Associated With Poor Prognosis in Patients With Non-HBV-Related HCC
- Volume 60Issue 11-12Alimentary Pharmacology & Therapeutics
- pages: 1645-1646
- First Published online: October 11, 2024
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Letter: Positivity of High-Sensitivity HBsAg Test Was Significantly Associated With Poorer Prognosis in Patients With Non-HBV-Related HCC—Authors' Reply
- Volume 60Issue 11-12Alimentary Pharmacology & Therapeutics
- pages: 1647-1649
- First Published online: October 11, 2024
Naohiro Yasuura
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Investigation, Formal analysis
Search for more papers by this authorCorresponding Author
Goki Suda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Correspondence
Goki Suda and Naoya Sakamoto, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Email: [email protected] and [email protected]
Contribution: Conceptualization, Methodology, Investigation, Funding acquisition, Writing - original draft, Writing - review & editing
Search for more papers by this authorMasatsugu Ohara
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Formal analysis, Validation, Investigation, Writing - review & editing
Search for more papers by this authorAkimitsu Meno
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Writing - review & editing, Data curation
Search for more papers by this authorTakuya Sho
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorRisako Kohya
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTakashi Sasaki
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTomoka Yoda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Investigation
Search for more papers by this authorSonoe Yoshida
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorQingjie Fu
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorZijian Yang
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorShunichi Hosoda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorOsamu Maehara
Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorShunsuke Ohnishi
Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTomoya Saitou
Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Contribution: Data curation, Investigation
Search for more papers by this authorMasaya Sugiyama
Department of Viral Pathogenesis and Controls, National Center for Global Health Medicine, Tokyo, Japan
Contribution: Writing - review & editing, Supervision
Search for more papers by this authorTakasuke Fukuhara
Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorMasaru Baba
Center for Gastroenterology and Hepatology, Japan Community Healthcare Organization Hokkaido Hospital, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTakashi Kitagataya
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorNaoki Kawagishi
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorMasato Nakai
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorMitsuteru Natsuizaka
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Supervision, Writing - review & editing
Search for more papers by this authorKoji Ogawa
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorAkinobu Taketomi
Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Contribution: Writing - review & editing, Supervision, Funding acquisition
Search for more papers by this authorCorresponding Author
Naoya Sakamoto
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Correspondence
Goki Suda and Naoya Sakamoto, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Email: [email protected] and [email protected]
Contribution: Supervision, Writing - review & editing, Funding acquisition
Search for more papers by this authorNaohiro Yasuura
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Investigation, Formal analysis
Search for more papers by this authorCorresponding Author
Goki Suda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Correspondence
Goki Suda and Naoya Sakamoto, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Email: [email protected] and [email protected]
Contribution: Conceptualization, Methodology, Investigation, Funding acquisition, Writing - original draft, Writing - review & editing
Search for more papers by this authorMasatsugu Ohara
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Formal analysis, Validation, Investigation, Writing - review & editing
Search for more papers by this authorAkimitsu Meno
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Writing - review & editing, Data curation
Search for more papers by this authorTakuya Sho
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorRisako Kohya
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTakashi Sasaki
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTomoka Yoda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Investigation
Search for more papers by this authorSonoe Yoshida
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorQingjie Fu
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorZijian Yang
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorShunichi Hosoda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorOsamu Maehara
Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorShunsuke Ohnishi
Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTomoya Saitou
Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Contribution: Data curation, Investigation
Search for more papers by this authorMasaya Sugiyama
Department of Viral Pathogenesis and Controls, National Center for Global Health Medicine, Tokyo, Japan
Contribution: Writing - review & editing, Supervision
Search for more papers by this authorTakasuke Fukuhara
Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorMasaru Baba
Center for Gastroenterology and Hepatology, Japan Community Healthcare Organization Hokkaido Hospital, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorTakashi Kitagataya
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorNaoki Kawagishi
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorMasato Nakai
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorMitsuteru Natsuizaka
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation, Supervision, Writing - review & editing
Search for more papers by this authorKoji Ogawa
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Contribution: Data curation
Search for more papers by this authorAkinobu Taketomi
Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Contribution: Writing - review & editing, Supervision, Funding acquisition
Search for more papers by this authorCorresponding Author
Naoya Sakamoto
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Correspondence
Goki Suda and Naoya Sakamoto, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Email: [email protected] and [email protected]
Contribution: Supervision, Writing - review & editing, Funding acquisition
Search for more papers by this authorNaohiro Yasuura, Goki Suda, and Masatsugu Ohara contributed equally to this work.
The Handling Editor for this article was Professor Geoffrey Dusheiko, and it was accepted for publication after full peer-review.
Summary
Background and Aims
The prognostic impact of previous-HBV-infection (pHBV) in non-HBV-related hepatocellular carcinoma (non-HBV-related-HCC) and the prevalence, characteristics and significance of recently developed high-sensitivity HBs antigen positivity (hHBsAg+) in these patients remain unclear. We aimed to close these gaps.
Methods
We retrospectively screened patients with newly diagnosed non-HBV-related-HCC (standard HBsAg-test negative) at Hokkaido University. Patients with complete clinical information and preserved serum for hHBsAg+ were included. We evaluated the prevalence, characteristics and prognostic impact of pHBV and hHBsAg+ in non-HBV-related-HCC.
Results
A total of 401 non-HBV-related-HCC patients were included (288 with pHBV/113 without pHBV). In non-HBV-related-HCC, pHBV did not affect overall survival (OS). Among non-HBV-related-HCC patients with pHBV, 11.8% (34/288) were hHBsAg+ and had more advanced stages of HCC, higher AFP levels, higher vascular invasion rates, and significantly shorter OS than others (OS: 19.3 vs. 61.4 months, p = 0.012). Comparison of OS among non-HBV-related-HCC patients without pHBV (group 1), those with pHBV and without hHBsAg+ (group 2), and those with pHBV and hHBsAg+ (group 3) revealed significantly shorter OS in group 3 (19.3, 56.6 and 66.4 months in groups 1, 2 and 3, respectively; p = 0.036). Multivariate Cox regression indicated that compared with group 1, only group 3 was significantly and independently associated with shorter OS (HR: 2.044, p = 0.011). Subgroup analysis revealed that this association was particularly evident in non-HBV-related-HCC patients with non-B-non-C aetiology and advanced HCC.
Conclusions
In non-HBV-related-HCC patients, hHBsAg+, not pHBV, is significantly and independently associated with poor prognosis.
Open Research
DATA AVAILABILITY STATEMENT
All data generated or analysed during this study are included in this article. Further inquiries can be directed to the corresponding author.
Supporting Information
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| apt18229-sup-0001-Supinfo.docxWord 2007 document , 292.7 KB |
Data S1. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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