Review Article
Review article: a comparison of glucagon-like peptides 1 and 2
P. Janssen,
A. Rotondo,
F. Mulé,
J. Tack,
P. Janssen
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
Search for more papers by this authorA. Rotondo
Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Palermo, Italy
Search for more papers by this authorF. Mulé
Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Palermo, Italy
Search for more papers by this authorCorresponding Author
J. Tack
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
Correspondence to:
Prof. J. Tack, Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
E-mail: [email protected]
Search for more papers by this authorP. Janssen,
A. Rotondo,
F. Mulé,
J. Tack,
P. Janssen
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
Search for more papers by this authorA. Rotondo
Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Palermo, Italy
Search for more papers by this authorF. Mulé
Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Palermo, Italy
Search for more papers by this authorCorresponding Author
J. Tack
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
Correspondence to:
Prof. J. Tack, Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
E-mail: [email protected]
Search for more papers by this authorThis uncommissioned review article was subject to full peer-review.
Summary
Background
Recent advancements in understanding the roles and functions of glucagon-like peptide 1 (GLP-1) and 2 (GLP-2) have provided a basis for targeting these peptides in therapeutic strategies.
Aim
To summarise the preclinical and clinical research supporting the discovery of new therapeutic molecules targeting GLP-1 and GLP-2.
Methods
This review is based on a comprehensive PubMed search, representing literature published during the past 30 years related to GLP-1 and GLP-2.
Results
Although produced and secreted together primarily from L cells of the intestine in response to ingestion of nutrients, GLP-1 and GLP-2 exhibit distinctive biological functions that are governed by the expression of their respective receptors, GLP-1R and GLP-2R. Through widespread expression in the pancreas, intestine, nervous tissue, et cetera, GLP-1Rs facilitates an incretin effect along with effects on appetite and satiety. GLP-1 analogues resistant to degradation by dipeptidyl peptidase-IV and inhibitors of dipeptidyl peptidase-IV have been developed to aid treatment of diabetes and obesity. The GLP-2R is expressed almost exclusively in the stomach and bowel. The most apparent role for GLP-2 is its promotion of growth and function of intestinal mucosa, which has been targeted for therapies that promote repair and adaptive growth. These are used as treatments for intestinal failure and related conditions.
Conclusions
Our growing understanding of the biology and function of GLP-1, GLP-2 and corresponding receptors has fostered further discovery of fundamental biological function as well as new categories of potent therapeutic medicines.
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