Changes in choroidal thickness and blood flow in myopic children with 0.01% atropine or orthokeratology and atropine combination therapy
Corresponding Author
Saiko Matsumura
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Correspondence
Saiko Matsumura, Department of Ophthalmology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo 143-8540, Japan.
Email: [email protected]
Search for more papers by this authorTakashi Itokawa
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorMomoko Kawakami
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorTadashi Matsumoto
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorHitoshi Ishikawa
Department of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
Search for more papers by this authorYuichi Hori
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Saiko Matsumura
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Correspondence
Saiko Matsumura, Department of Ophthalmology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo 143-8540, Japan.
Email: [email protected]
Search for more papers by this authorTakashi Itokawa
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorMomoko Kawakami
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorTadashi Matsumoto
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorHitoshi Ishikawa
Department of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
Search for more papers by this authorYuichi Hori
Department of Ophthalmology, Toho University Faculty of Medicine, Tokyo, Japan
Search for more papers by this authorAbstract
Purpose
To evaluate changes in choroidal thickness (CT), choroidal blood flow and axial length (AL) after therapy with either 0.01% atropine eye drops (AT) or the combination of orthokeratology and 0.01% AT (OKA) among Japanese myopic children.
Methods
We analysed changes in CT, choroidal blood flow and AL among myopic children who received either 0.01% AT or the OKA therapy at Toho University Omori Hospital from January 2021 through December 2022 (n = 38 eyes, 8.26 ± 2.13 years old in the 0.01% AT group and n = 44 eyes, 8.36 ± 1.54 years old in the OKA group). Comprehensive ophthalmologic examinations were performed at baseline, 3, 6 and 12 months.
Results
Subfoveal CT increased in the OKA group more than that in the AT group at 3, 6 and 12 months. Choroidal blood flow increase was greater in the OKA group compared to that in the AT group at 6 and 12 months. AL increase was less in the OKA group than that in the AT group at 6 and 12 months. AL changes were negatively correlated with choroidal blood flow and CT changes at both time points. In multivariate analysis, age, male, CT change and choroidal blood flow were independently associated with AL changes at 12 months.
Conclusion
The increase in CT was more pronounced in the combination therapy group compared to the AT group. The increase in CT and choroidal blood flow was associated with a reduced AL progression.
Supporting Information
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| aos17537-sup-0001-Supinfo1.docxWord 2007 document , 17.1 KB |
Data S1. |
| aos17537-sup-0002-Supinfo2.docxWord 2007 document , 38.7 KB |
Data S2. |
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