Dynamic gray matter and intrinsic activity changes after epilepsy surgery
Wei Li
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorYuchao Jiang
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China
Search for more papers by this authorYingjie Qin
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorBaiwan Zhou
Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorDu Lei
Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorCheng Luo
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China
Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, China
Search for more papers by this authorHeng Zhang
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorCorresponding Author
Qiyong Gong
Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dongmei An and Dong Zhou, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Emails: [email protected]; [email protected]
Qiyong Gong, Department of Radiology, Huaxi MR Research Center, Center for Medical Imaging, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dong Zhou
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dongmei An and Dong Zhou, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Emails: [email protected]; [email protected]
Qiyong Gong, Department of Radiology, Huaxi MR Research Center, Center for Medical Imaging, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dongmei An
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dongmei An and Dong Zhou, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Emails: [email protected]; [email protected]
Qiyong Gong, Department of Radiology, Huaxi MR Research Center, Center for Medical Imaging, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Email: [email protected]
Search for more papers by this authorWei Li
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorYuchao Jiang
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China
Search for more papers by this authorYingjie Qin
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorBaiwan Zhou
Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorDu Lei
Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorCheng Luo
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China
Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, China
Search for more papers by this authorHeng Zhang
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
Search for more papers by this authorCorresponding Author
Qiyong Gong
Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dongmei An and Dong Zhou, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Emails: [email protected]; [email protected]
Qiyong Gong, Department of Radiology, Huaxi MR Research Center, Center for Medical Imaging, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dong Zhou
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dongmei An and Dong Zhou, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Emails: [email protected]; [email protected]
Qiyong Gong, Department of Radiology, Huaxi MR Research Center, Center for Medical Imaging, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dongmei An
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Dongmei An and Dong Zhou, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Emails: [email protected]; [email protected]
Qiyong Gong, Department of Radiology, Huaxi MR Research Center, Center for Medical Imaging, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Email: [email protected]
Search for more papers by this authorAbstract
Objectives
To explore the dynamic changes of gray matter volume and intrinsic brain activity following anterior temporal lobectomy (ATL) in patients with unilateral mesial temporal lobe epilepsy (mTLE) who achieved seizure-free for 2 years.
Materials and Methods
High-resolution T1-weighted MRI and resting-state functional MRI data were obtained in ten mTLE patients at five serial timepoints: before surgery, 3, 6, 12, and 24 months after surgery. The gray matter volume (GMV) and amplitude of low-frequency fluctuations (ALFF) were compared among the five scans to depict the dynamic changes after ATL.
Results
After successful ATL, GMV decreased in several ipsilateral brain regions: ipsilateral insula, thalamus, and putamen showed gradual gray matter atrophy from 3 to 24 months, while ipsilateral superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, middle occipital gyrus, inferior occipital gyrus, caudate nucleus, lingual gyrus, and fusiform gyrus showed significant GMV decrease at 3 months follow-up, without further changes. Ipsilateral insula showed gradual ALFF decrease from 3 to 24 months after surgery. Ipsilateral superior temporal gyrus showed ALFF decrease at 3 months follow-up, without further changes. Ipsilateral thalamus and cerebellar vermis showed obvious ALFF increase after surgery.
Conclusions
Surgical resection may lead to a short-term reduction of gray matter volume and intrinsic brain activity in neighboring regions, while the progressive gray matter atrophy may be due to possible intrinsic mechanism of mTLE. Dynamic ALFF changes provide evidence that disrupted focal spontaneous activities were reorganized after successful surgery.
CONFLICT OF INTEREST
None of the authors has any conflict of interest to disclose.
Open Research
DATA AVAILABILITY STATEMENT
Anonymized data will be shared by request from any qualified investigator.
Supporting Information
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Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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