CD25+FOXP3+ and CD4+CD25+ cells distribution in decidual departments of women with severe and mild pre-eclampsia: Comparison with healthy pregnancies
Corresponding Author
Martina Orlovic Vlaho
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Correspondence
Orlovic Vlaho Martina, Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.
Email: [email protected]
Search for more papers by this authorVajdana Tomic
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Faculty of Health Studies, University of Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorKatarina Vukojevic
Laboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina
Laboratory for Early Human Development, Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Split, Croatia
Search for more papers by this authorAnja Vasilj
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorRenato Pejic
University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorJosip Lesko
University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorVioleta Soljic
Laboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorCorresponding Author
Martina Orlovic Vlaho
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Correspondence
Orlovic Vlaho Martina, Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.
Email: [email protected]
Search for more papers by this authorVajdana Tomic
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Faculty of Health Studies, University of Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorKatarina Vukojevic
Laboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina
Laboratory for Early Human Development, Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Split, Croatia
Search for more papers by this authorAnja Vasilj
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorRenato Pejic
University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorJosip Lesko
University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorVioleta Soljic
Laboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina
Search for more papers by this authorAbstract
Problem
The aim of this study was to quantify and compare the distribution of regulatory CD25+FOXP3+ and activated CD4+CD25+ T cells in decidua basalis and parietalis of severe and mild pre-eclampsia (PE) to normal healthy pregnancies.
Method of study
Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence.
Results
The total number of CD25+FOXP3+ cells/mm2 in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4+CD25+ cells/mm2 in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25+FOXP3+ and CD4+CD25+ cells in decidua parietalis was decreased in both PE groups.
Conclusion
Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.
CONFLICT OF INTEREST
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.
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