Review Article
Viral Infections During Pregnancy
Michelle Silasi,
Ingrid Cardenas,
Ja-Young Kwon,
Karen Racicot,
Paula Aldo,
Gil Mor,
Michelle Silasi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorIngrid Cardenas
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorJa-Young Kwon
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
Search for more papers by this authorKaren Racicot
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorPaula Aldo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorCorresponding Author
Gil Mor
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Correspondence
Gil Mor, Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Reproductive Sciences, Yale University School of Medicine, 333 Cedar St., LSOG 305A, New Haven, CT 06520, USA.
E-mail: [email protected]
Search for more papers by this authorMichelle Silasi,
Ingrid Cardenas,
Ja-Young Kwon,
Karen Racicot,
Paula Aldo,
Gil Mor,
Michelle Silasi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorIngrid Cardenas
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorJa-Young Kwon
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
Search for more papers by this authorKaren Racicot
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorPaula Aldo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Search for more papers by this authorCorresponding Author
Gil Mor
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Correspondence
Gil Mor, Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Reproductive Sciences, Yale University School of Medicine, 333 Cedar St., LSOG 305A, New Haven, CT 06520, USA.
E-mail: [email protected]
Search for more papers by this authorAbstract
Viral infections during pregnancy have long been considered benign conditions with a few notable exceptions, such as herpes virus. The recent Ebola outbreak and other viral epidemics and pandemics show how pregnant women suffer worse outcomes (such as preterm labor and adverse fetal outcomes) than the general population and non-pregnant women. New knowledge about the ways the maternal–fetal interface and placenta interact with the maternal immune system may explain these findings. Once thought to be ‘immunosuppressed’, the pregnant woman actually undergoes an immunological transformation, where the immune system is necessary to promote and support the pregnancy and growing fetus. When this protection is breached, as in a viral infection, this security is weakened and infection with other microorganisms can then propagate and lead to outcomes, such as preterm labor. In this manuscript, we review the major viral infections relevant to pregnancy and offer potential mechanisms for the associated adverse pregnancy outcomes.
References
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