Familial factors associated with development of alcohol and mental health comorbidity
Corresponding Author
Caroline L. Salom
School of Population Health, The University of Queensland, Herston, Australia
Correspondence to: Caroline Salom, School of Population Health, University of Queensland, Herston Road, Herston, Queensland 4006, Australia. E-mail: [email protected]Search for more papers by this authorGail M. Williams
School of Population Health, The University of Queensland, Herston, Australia
Search for more papers by this authorJake M. Najman
School of Population Health, The University of Queensland, Herston, Australia
School of Social Science, University of Queensland, Herston, Australia
Search for more papers by this authorRosa Alati
School of Population Health, The University of Queensland, Herston, Australia
Centre for Youth Substance Abuse Research, The University of Queensland, Herston, Australia
Search for more papers by this authorCorresponding Author
Caroline L. Salom
School of Population Health, The University of Queensland, Herston, Australia
Correspondence to: Caroline Salom, School of Population Health, University of Queensland, Herston Road, Herston, Queensland 4006, Australia. E-mail: [email protected]Search for more papers by this authorGail M. Williams
School of Population Health, The University of Queensland, Herston, Australia
Search for more papers by this authorJake M. Najman
School of Population Health, The University of Queensland, Herston, Australia
School of Social Science, University of Queensland, Herston, Australia
Search for more papers by this authorRosa Alati
School of Population Health, The University of Queensland, Herston, Australia
Centre for Youth Substance Abuse Research, The University of Queensland, Herston, Australia
Search for more papers by this authorAbstract
Background and Aims
Co-occurring mental health and alcohol problems appear to be associated with greater health burdens than either single disorder. This study compares familial and individual contributions to development of comorbid alcohol/mental problems and tests whether these differ from single disorders.
Design
Women (n = 6703) were recruited during pregnancy to the longitudinal Mater-University of Queensland Study of Pregnancy (MUSP). Mother/offspring dyads were followed over 21 years.
Setting
Mater-Misericordiae Public Hospital, Brisbane, Australia.
Participants
Primary offspring from the MUSP with full psychiatric information at 21 years and maternal information at age 14 (n = 1755).
Measurements
Structured interviews at age 21 yielded a four-category outcome using mental health and alcohol modules of the Composite International Diagnostic Interview (no disorder, alcohol only, mental health only and comorbid alcohol/mental health). Multinomial logistic regression models were adjusted for gender, maternal mental health and substance use, family environment and adolescent behaviour.
Findings
Maternal smoking [odds ratio (OR) = 1.56; 95% confidence interval (CI) = 1.09–2.22 versus no-disorder] and low mother–offspring warmth (OR = 3.19; 95% CI = 1.99–5.13) were associated with mental health/alcohol comorbidity in young adults, as were adolescent drinking (OR = 2.22; 95% CI = 1.25–3.96), smoking (OR = 2.24; 95% CI = 1.33–3.77) and attention/thought problems (OR = 2.04; 95% CI = 1.18–3.52). Some differences were seen from single disorders. In a subsample with paternal data, fathers' drinking problems (OR = 2.41; 95% CI = 1.10–5.29) were more associated strongly with offspring mental health/alcohol comorbidity than both single disorders (P < 0.05).
Conclusions
Maternal smoking and low mother–child warmth appear to be related to alcohol, mental health and comorbid disorders at age 21, possibly via constituent alcohol and mental health disorders. Adolescent drinking and attention/thought problems appear to be associated with comorbid disorders but not with individual alcohol and mental health disorders.
Supporting Information
| Filename | Description |
|---|---|
| add12722-sup-0001-documentS1.docxapplication/unknown, 44.5 KB | Table S1 Alcohol and mental health disorders at age 21. Table S2 Multinomial logistic regression model of young adult comorbidity class, by maternal factors, family environment and adolescent behaviour. Table S3 Multivariable attrition analysis showing the likelihood of being lost to follow-up (LFU) at age 21 according to baseline factors. Table S4 Effect of multiple imputation on model. Table S5 Multinomial logistic regression model of young adult comorbidity class, after exclusion of individuals with non-alcohol substance disorders. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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