Commentary
Biological Systems Are a Common Link Between Alcohol Use Disorder and Co-Occurring Psychiatric and Medical Conditions
Sarah L. Hagerty,
Jarrod M. Ellingson,
Kent E. Hutchison,
Corresponding Author
Sarah L. Hagerty
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado
Reprint requests: Sarah L. Hagerty, MA, Department of Psychology and Neuroscience, University of Colorado Boulder, 345 UCB Boulder, CO 80309; Tel.: 303-492-9147; Fax: 303-492-2967; E-mail: [email protected]Search for more papers by this authorJarrod M. Ellingson
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado
Search for more papers by this authorKent E. Hutchison
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado
Search for more papers by this authorSarah L. Hagerty,
Jarrod M. Ellingson,
Kent E. Hutchison,
Corresponding Author
Sarah L. Hagerty
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado
Reprint requests: Sarah L. Hagerty, MA, Department of Psychology and Neuroscience, University of Colorado Boulder, 345 UCB Boulder, CO 80309; Tel.: 303-492-9147; Fax: 303-492-2967; E-mail: [email protected]Search for more papers by this authorJarrod M. Ellingson
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado
Search for more papers by this authorKent E. Hutchison
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado
Search for more papers by this author
References
- Amato KR (2017) An introduction to microbiome analysis for human biology applications. Am J Hum Biol doi: 10.1002/ajhb.22931 [Epub].
10.1002/ajhb.22931 Google Scholar
- Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M (2011) Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun 25: 397–407.
- Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, Monteith P, Noble NA, Unser AB, Daita K, Fisher AR, Sikaroodi M, Gillevet PM (2014) Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 60: 940–947.
- Bala S, Marcos M, Gattu A, Catalano D, Szabo G (2014) Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One 9: e96864.
- Barcia JM, Flores-Bellver M, Muriach M, Sancho-Pelluz J, Lopez-Malo D, Urdaneta AC, Martinez-Gil N, Atienzar-Aroca S, Romero FJ (2015) Matching diabetes and alcoholism: oxidative stress, inflammation, and neurogenesis are commonly involved. Mediators Inflamm. Available at: https://www.hindawi.com/journals/mi/2015/624287/abs/. Accessed November 21, 2017.
- Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA (2011) Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun 25: S92–S105.
- Collins SM, Bercik P (2009) The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136: 2003–2014.
- Fernandez-Lizarbe S, Montesinos J, Guerri C (2013) Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells. J Neurochem 126: 261–273.
- Goodell S, Druss BG, Walker ER, Mat M (2011) Mental disorders and medical comorbidity. The Synthesis Project.
- Halaris A (2016) Inflammation-associated co-morbidity between depression and cardiovascular disease, in Inflammation-Associated Depression: Evidence, Mechanisms and Implications, Current Topics in Behavioral Neurosciences ( R Dantzer, L Capuron eds), pp 45–70. Springer, Cham.
- Heckers S (2015) The value of psychiatric diagnoses. JAMA Psychiatry 72: 1165–1166.
- Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289: 3095–3105.
- Leclercq S, Cani PD, Neyrinck AM, Stärkel P, Jamar F, Mikolajczak M, Delzenne NM, de Timary P (2012) Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain Behav Immun 26: 911–918.
- Leclercq S, de Timary P, Delzenne NM, Stärkel P (2017) The link between inflammation, bugs, the intestine and the brain in alcohol dependence. Transl Psychiatry 7: e1048.
- Leclercq S, Matamoros S, Cani PD, Neyrinck AM, Jamar F, Stärkel P, Windey K, Tremaroli V, Bäckhed F, Verbeke K, de Timary P, Delzenne NM (2014) Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci USA 111: E4485–E4493.
- Malaguarnera G, Giordano M, Nunnari G, Bertino G, Malaguarnera M (2014) Gut microbiota in alcoholic liver disease: pathogenetic role and therapeutic perspectives. World J Gastroenterol 20: 16639–16648.
- Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, Kwasny M, Lau CK, Keshavarzian A (2012) Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 302: G966–G978.
- Neale MC, Kendler KS (1995) Models of comorbidity for multifactorial disorders. Am J Hum Genet 57: 935–953.
- O'Keefe JH, Bybee KA, Lavie CJ (2007) Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 50: 1009–1014.
- Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR (2008) Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol 42: 349–361.
- Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27: 24–31.
- Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J (2009) Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373: 2223–2233.
- Rehm J, Room R, Monteiro M, Gmel G, Graham K, Rehn N, Sempos CT, Jernigan D (2003) Alcohol as a risk factor for global burden of disease. Eur Addict Res 9: 157–164.
- Rogers GB, Keating DJ, Young RL, Wong M-L, Licinio J, Wesselingh S (2016) From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry 21: 738–748.
- Szabo G (2015) Gut-liver axis in alcoholic liver disease. Gastroenterology 148: 30–36.
- Wang HJ, Zakhari S, Jung MK (2010) Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J Gastroenterol 16: 1304–1313.
