International Journal of Rheumatic Diseases

Original Article

MICB002* and MICB014* protect against rheumatoid arthritis, whereas MICA009* and MICAA6* are associated with rheumatoid arthritis in a Hainan Han Chinese population

Yong Wang

orcid.org/0000-0002-4916-7368

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

Department of Forensic Science, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Sangsang Li,

Sangsang Li

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Chunjing Chen,

Chunjing Chen

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Qizhi Luo,

Qizhi Luo

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Yu Li,

Yu Li

Department of Basic Medicine and Clinical Laboratory, Yiyang Medical College, Yiyang, Hunan, China

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Limin Liu,

Limin Liu

Liuzhou Worker's Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China

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Xiaoling Fu,

Xiaoling Fu

Department of Blood Transfusion, Hainan General Hospital, Haikou, Hainan, China

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Ping Yu,

Ping Yu

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Fuyan Wang,

Corresponding Author

Fuyan Wang

[email protected]

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

Correspondence: Professor Fuyan Wang, Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, China. Email: [email protected]Search for more papers by this author

Yong Wang,

Yong Wang

orcid.org/0000-0002-4916-7368

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

Department of Forensic Science, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Sangsang Li,

Sangsang Li

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Chunjing Chen,

Chunjing Chen

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Qizhi Luo,

Qizhi Luo

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Yu Li,

Yu Li

Department of Basic Medicine and Clinical Laboratory, Yiyang Medical College, Yiyang, Hunan, China

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Limin Liu,

Limin Liu

Liuzhou Worker's Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China

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Xiaoling Fu,

Xiaoling Fu

Department of Blood Transfusion, Hainan General Hospital, Haikou, Hainan, China

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Ping Yu,

Ping Yu

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

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Fuyan Wang,

Corresponding Author

Fuyan Wang

[email protected]

Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China

First published: 17 April 2018

https://doi.org/10.1111/1756-185X.13302

Citations: 5

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Abstract

Aim

Rheumatoid arthritis (RA) as an inflammatory autoimmune disease affects the synovial joints as well as other organs and tissues. Since aberrant expression of MIC molecules has been observed in RA patient, MIC genotypes might play certain roles in the development of RA.

Method

To explore the association of MICA and MICB polymorphisms with RA in a Han Chinese population in Hainan Island, samples from 172 RA and 137 healthy controls were genotyped for MICA and MICB.

Results

Our results indicated that MICB*002 and MICB*014 were less frequent in RA patients than in controls (P = 0.000, 0.005) while there were higher percentages of RA patients carrying MICA*009 and MICA*A6 (P = 0.005).

Conclusion

Different MIC variants might modulate the autoimmune reaction differently in RA disease and therefore serve as protective or risk factors.

Disclosure of Conflicts of Interest

The authors declare that they have no conflict of interests.

References

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Citing Literature

Volume22, Issue1

January 2019

Pages 90-95

MICB002* and MICB014* protect against rheumatoid arthritis, whereas MICA009* and MICAA6* are associated with rheumatoid arthritis in a Hainan Han Chinese population

Abstract

Aim

Method

Results

Conclusion

Disclosure of Conflicts of Interest

References

Citing Literature

References

Information

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MICB*002 and MICB*014 protect against rheumatoid arthritis, whereas MICA*009 and MICA*A6 are associated with rheumatoid arthritis in a Hainan Han Chinese population

Abstract

Aim

Method

Results

Conclusion

Disclosure of Conflicts of Interest

References

Citing Literature

References

Related

Information

MICB002* and MICB014* protect against rheumatoid arthritis, whereas MICA009* and MICAA6* are associated with rheumatoid arthritis in a Hainan Han Chinese population