Association between physical function and hospitalization among older patients with pre-dialysis chronic kidney disease after educational hospitalization: A single-center prospective cohort study
Corresponding Author
Aki Tabata
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Correspondence
Aki Tabata, Department of Rehabilitation, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura-shi, Chiba 285-8765, Japan.
Email: [email protected]
Search for more papers by this authorHiroki Yabe
Department of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, Shizuoka, Japan
Search for more papers by this authorTakehide Katogi
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorYuya Mitake
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorShunta Oono
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorTakayuki Fujii
Department of Nephrology, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorCorresponding Author
Aki Tabata
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Correspondence
Aki Tabata, Department of Rehabilitation, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura-shi, Chiba 285-8765, Japan.
Email: [email protected]
Search for more papers by this authorHiroki Yabe
Department of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, Shizuoka, Japan
Search for more papers by this authorTakehide Katogi
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorYuya Mitake
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorShunta Oono
Department of Rehabilitation, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorTakayuki Fujii
Department of Nephrology, Seirei Sakura Citizen Hospital, Chiba, Japan
Search for more papers by this authorAbstract
Introduction
This study aimed to investigate the factors associated with hospitalization in older patients with pre-dialysis CKD, including physical function.
Methods
This single-center, prospective cohort study included 111 patients aged ≥65 years with stage 3–5 non-hemodialyzed CKD. Physical function was assessed using the short physical performance battery (SPPB), 10-m walk test, and grip strength test. Hospitalizations and reasons for readmission were tracked from discharge to the end of the follow-up period.
Results
Kaplan–Meier analysis showed significant associations between rehospitalization and SPPB, 10-meter walk speed, and grip strength. The cutoff values predicting rehospitalization were 11 points for SPPB, 1.1 m/s for 10-meter walk speed, and 31 kg for grip strength. Multivariate Cox regression revealed that SPPB, hemoglobin, and estimated glomerular filtration rate (eGFR) were independently associated with rehospitalization risk.
Conclusions
SPPB may predict hospitalization in older pre-dialysis CKD patients, emphasizing the importance of screening and preventing physical function decline.
CONFLICT OF INTEREST STATEMENT
The authors have declared that no conflict of interest exists.
REFERENCES
- 1Takeuchi M, Shinkawa K, Yanagita M, Kawakami K. Prevalence, recognition and management of chronic kidney disease in Japan: population-based estimate using a healthcare database with routine health checkup data. Clin Kidney J. 2021; 14: 2197–2202.
- 2Iimuro S, Kaneko T, Ohashi Y, Watanabe T, Nitta K, Akizawa T, et al. Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study. Clin Exp Nephrol. 2019; 23: 956–968.
- 3Soysal P, Heybeli C, Koc Okudur S, Caliskan Bozyel E, Smith L, Kazancioglu R. Prevalence and co-incidence of geriatric syndromes according to glomerular filtration rate in older patients. Int Urol Nephrol. 2023; 55: 469–476.
- 4Goto NA, Hamaker ME, Willems HC, Verhaar MC, Emmelot-Vonk MH. Accidental falling in community-dwelling elderly with chronic kidney disease. Int Urol Nephrol. 2019; 51: 119–127.
- 5Chou CY, Wang SM, Liang CC, Chang CT, Liu JH, Wang IK, et al. Risk of pneumonia among patients with chronic kidney disease in outpatient and inpatient settings: a nationwide population-based study. Medicine. 2014; 93:e174.
- 6Jalal SM, Beth MRM, Bo Khamseen ZM. Impact of hospitalization on the quality of life of patients with chronic kidney disease in Saudi Arabia. Int J Environ Res Public Health. 2022; 19: 9718.
- 7Baumeister SE, Böger CA, Krämer BK, Doring A, Eheberg D, Fischer B, et al. Effect of chronic kidney disease and comorbid conditions on health care costs: a 10-year observational study in a general population. Am J Nephrol. 2010; 31: 222–229.
- 8Schrauben SJ, Chen HY, Lin E, Jepson C, Yang W, Scialla JJ, et al. Hospitalizations among adults with chronic kidney disease in the United States: a cohort study. PLoS Med. 2020; 17:e1003470.
- 9Hiraki K, Yasuda T, Hotta C, Izawa KP, Morio Y, Watanabe S, et al. Decreased physical function in pre-dialysis patients with chronic kidney disease. Clin Exp Nephrol. 2013; 17: 225–231.
- 10Tsai YC, Chen HM, Hsiao SM, Chen CS, Lin MY, Chiu YW, et al. Association of physical activity with cardiovascular and renal outcomes and quality of life in chronic kidney disease. PLoS One. 2017; 12:e0183642.
- 11Roshanravan B, Robinson-Cohen C, Patel KV, Ayers E, Littman AJ, de Boer IH, et al. Association between physical performance and all-cause mortality in CKD. J Am Soc Nephrol. 2013; 24: 822–830.
- 12Uchida J, Suzuki Y, Imamura K, Yoshikoshi S, Nakajima T, Fukuzaki N, et al. The association of short physical performance battery with mortality and hospitalization in patients receiving hemodialysis. J Ren Nutr. 2024; 34: 235–242.
- 13Yabe H, Imoto Y, Onoyama A, Ito S, Kono K, Moriyama Y, et al. Six-minute walk distance predicts hospitalization in elderly peritoneal dialysis patients: a single-center prospective cohort study. Ren Replace Ther. 2021; 7: 7.
10.1186/s41100-021-00354-8 Google Scholar
- 14Lee LY, Tung HH, Tsay SL, Chen YC, Lee HH, Zeng YX, et al. Predictors for self-management in older adults with type 2 diabetic nephropathy. J Clin Nurs. 2020; 29: 922–931.
- 15Segura-Ortí E, Gordon PL, Doyle JW, Johansen KL. Correlates of physical functioning and performance across the spectrum of kidney function. Clin Nurs Res. 2018; 27: 579–596.
- 16Shirai N, Yamamoto S, Osawa Y, Tsubaki A, Morishita S, Sugahara T, et al. Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass. Clin Exp Nephrol. 2024; 28: 67–74.
- 17Choi HC, Son KY, Cho B, Park SM, Cho SI. An implication of the short physical performance battery (SPPB) as a predictor of abnormal pulmonary function in aging people. Arch Gerontol Geriatr. 2012; 54: 448–452.
- 18Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent JP, Nicolis I, et al. Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr. 2005; 82: 777–783.
- 19Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994; 49: M85–M94.
- 20Wiebe N, Klarenbach SW, Allan GM, Manns BJ, Pelletier R, James MT, et al. Alberta kidney disease network. Potentially preventable hospitalization as a complication of CKD: a cohort study. Am J Kidney Dis. 2014; 64: 230–238.
- 21Stevens LA, Li S, Wang C, Huang C, Becker BN, Bomback AS, et al. Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the kidney early evaluation program (KEEP). Am J Kidney Dis. 2010; 55: S23–S33.
- 22Mix TC, St Peter WL, Ebben J, Xue J, Pereira BJ, Kausz AT, et al. Hospitalization during advancing chronic kidney disease. Am J Kidney Dis. 2003; 42: 972–981.
- 23Hao X, Zhang H, Zhao X, Peng X, Li K. Risk factors for hospitalization-associated disability among older patients: a systematic review and meta-analysis. Ageing Res Rev. 2024; 101:102516.
- 24Silva CFR, Gonçalves Ohara D, Pena Matos A, Nunes Pinto ACP, Sousa Pegorari M. Short physical performance battery as a predictor of mortality in community-dwelling older adults: a longitudinal study in the Brazilian Amazon region. PeerJ. 2022; 10:e13630.
- 25Falvey JR, Burke RE, Levy CR, Gustavson AM, Price L, Forster JE, et al. Impaired physical performance predicts hospitalization risk for participants in the program of all-inclusive Care for the Elderly. Phys Ther. 2019; 99: 28–36.
- 26Belkin MD, Doerfler RM, Wagner LA, Zhan M, Fink JC. Associations of performance-based functional assessments and adverse outcomes in CKD. Kidney360. 2021; 2: 629–638.
- 27Tsai YC, Wang SL, Tsai HJ, Chen TH, Kung LF, Hsiao PN, et al. The interaction between self-care behavior and disease knowledge on the decline in renal function in chronic kidney disease. Sci Rep. 2021; 11: 401.
- 28Wilund KR, Thompson S, Viana JL, Wang AY. Physical activity and health in chronic kidney disease. Contrib Nephrol. 2021; 199: 43–55.
- 29Schrauben SJ, Hsu JY, Rosas SE, Jaar BG, Zhang X, Doe R, et al. CKD self-management: phenotypes and associations with clinical outcomes. Am J Kidney Dis. 2018; 72: 360–370.
- 30Habas E Sr, Al Adab A, Arryes M, Alfitori G, Farfar K, Habas AM, et al. Anemia and hypoxia impact on chronic kidney disease onset and progression: review and updates. Cureus. 2023; 15:e46737.
- 31Silverberg D, Wexler D, Blum M, Wollman Y, Iaina A. The cardio-renal anaemia syndrome: does it exist? Nephrol Dial Transplant. 2003; 18 Suppl 8: viii7–viii12.
- 32Kawai K, Ishii M, Kokado Y, Horikawa T, Hoshino J. Outcomes of early versus delayed anemia treatment in nondialysis-dependent CKD. Kidney Int Rep. 2024; 9: 2056–2066.
- 33Schnelle J, Osterweil D, Globe D, Sciarra A, Audhya P, Barlev A. Chronic kidney disease, anemia, and the association between chronic kidney disease-related anemia and activities of daily living in older nursing home residents. J Am Med Dir Assoc. 2009; 10: 120–126.
- 34Farag YMK, Blasco-Colmenares E, Zhao D, Sanon M, Guallar E, Finkelstein FO. Effect of anemia on physical function and physical activity in CKD: The National Health and Nutrition Examination Survey, 1999–2016. Kidney360. 2023; 4: e1212–e1222.
- 35Sá Martins V, Adragão T, Aguiar L, Pinto I, Dias C, Figueiredo R, et al. Prognostic value of the malnutrition-inflammation score in hospitalization and mortality on long-term hemodialysis. J Ren Nutr. 2022; 32: 569–577.
- 36Traise A, Dieberg G, Pearson MJ, Smart NA. The effect of exercise training in people with pre-dialysis chronic kidney disease: a systematic review with meta-analysis. J Nephrol. 2024; 37: 2063–2098.
- 37Kirkman DL, Ramick MG, Muth BJ, Stock JM, Pohlig RT, Townsend RR, et al. Effects of aerobic exercise on vascular function in nondialysis chronic kidney disease: a randomized controlled trial. Am J Physiol Renal Physiol. 2019; 316: F898–F905.
- 38Gute L, Zimbudzi E. Interventions to reduce falls among dialysis patients: a systematic review. BMC Nephrol. 2023; 24: 382.
- 39Abe M, Hatta T, Imamura Y, Sakurada T, Kaname S. Effectiveness and current status of multidisciplinary care for patients with chronic kidney disease in Japan: a nationwide multicenter cohort study. Clin Exp Nephrol. 2023; 27: 528–541.