Volume 29, Issue 3 pp. 357-364

ORIGINAL ARTICLE

Prognostic value of Glasgow prognostic score in patients undergoing hemodialysis

Ryosuke Sakamoto,

Ryosuke Sakamoto

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Kenta Torigoe,

Corresponding Author

Kenta Torigoe

[email protected]

orcid.org/0000-0003-3085-0391

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

Correspondence

Kenta Torigoe, Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.

Email: [email protected]

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Shinichi Abe,

Shinichi Abe

Nagasaki Renal Center, Nagasaki City, Nagasaki, Japan

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Mineaki Kitamura,

Mineaki Kitamura

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Satoshi Funakoshi,

Satoshi Funakoshi

Nagasaki Renal Center, Nagasaki City, Nagasaki, Japan

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Takahiro Takazono,

Takahiro Takazono

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Noriho Sakamoto,

Noriho Sakamoto

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Hiroshi Mukae,

Hiroshi Mukae

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Tomoya Nishino,

Tomoya Nishino

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Ryosuke Sakamoto,

Ryosuke Sakamoto

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Kenta Torigoe,

Corresponding Author

Kenta Torigoe

[email protected]

orcid.org/0000-0003-3085-0391

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

Correspondence

Kenta Torigoe, Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.

Email: [email protected]

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Shinichi Abe,

Shinichi Abe

Nagasaki Renal Center, Nagasaki City, Nagasaki, Japan

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Mineaki Kitamura,

Mineaki Kitamura

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Satoshi Funakoshi,

Satoshi Funakoshi

Nagasaki Renal Center, Nagasaki City, Nagasaki, Japan

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Takahiro Takazono,

Takahiro Takazono

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Noriho Sakamoto,

Noriho Sakamoto

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Hiroshi Mukae,

Hiroshi Mukae

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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Tomoya Nishino,

Tomoya Nishino

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan

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First published: 26 March 2025

https://doi.org/10.1111/1744-9987.70014

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Abstract

Introduction

Usefulness of the Glasgow prognostic score (GPS), modified GPS (mGPS), and high-sensitivity mGPS (HS-mGPS) in the prognosis of patients undergoing hemodialysis remains unclear. This study aimed to investigate this.

Methods

The GPS, mGPS, and HS-mGPS were calculated retrospectively in 339 patients undergoing hemodialysis; their association with all-cause mortality was analyzed using the Kaplan–Meier method and Cox proportional hazards models.

Results

Survival rates decreased according to the GPS (0, 1, and 2), but were similar between the mGPS and HS-mGPS. In the multivariate Cox proportional hazards model, the GPS, not the mGPS or HS-mGPS, was associated with a higher risk of all-cause mortality in patients with scores 1 (hazard ratio [HR]: 1.76, 95% confidence interval [CI]: 1.29–2.42, p = 0.0004) and 2 (HR: 2.87, 95% CI: 1.91–4.32, p < 0.0001) compared with score 0.

Conclusions

The GPS classified patients into poor prognostic risk groups more clearly than other scores.

CONFLICT OF INTEREST STATEMENT

The authors have declared that no conflict of interest exists.

Open Research

DATA AVAILABILITY STATEMENT

The data presented in this study are available on request from the corresponding author.

Supporting Information

Filename	Description
tap70014-sup-0001-FigureS1.jpgJPEG image, 280.3 KB	FIGURE S1. Kaplan–Meier curves of the GPS, mGPS, and HS-mGPS based on the annual average CRP and Alb levels. Alb, albumin; CRP, C-reactive protein; GPS, Glasgow prognostic score; HS-mGPS, high-sensitivity modified Glasgow prognostic score; mGPS, modified Glasgow prognostic score.
tap70014-sup-0002-FigureS2.jpgJPEG image, 273.6 KB	FIGURE S2. ROC curve analysis of the GPS, mGPS, and HS-mGPS based on the annual average CRP and Alb levels. AUC, area under the curve; GPS, Glasgow prognostic score; HS-mGPS, high-sensitivity modified Glasgow prognostic score; mGPS, modified Glasgow prognostic score; ROC, receiver-operating characteristic.
tap70014-sup-0003-FigureS3.jpgJPEG image, 85.7 KB	FIGURE S3. Kaplan–Meier curves for hypoalbuminemia and high CRP levels in patients with a GPS score of 1. Alb, albumin; CRP, C-reactive protein; GPS, Glasgow prognostic score.
tap70014-sup-0004-TableS1.docxWord 2007 document , 17 KB	TABLE S1: Cox proportional-hazards model for the risk of mortality by GPS, mGPS or HS-mGPS (sensitivity analysis).

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Volume29, Issue3

June 2025

Pages 357-364

Prognostic value of Glasgow prognostic score in patients undergoing hemodialysis

Abstract

Introduction

Methods

Results

Conclusions

CONFLICT OF INTEREST STATEMENT

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

References

Information

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Prognostic value of Glasgow prognostic score in patients undergoing hemodialysis

Abstract

Introduction

Methods

Results

Conclusions

CONFLICT OF INTEREST STATEMENT

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

References

Related

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