Plasma Exchange Downregulates Activated Monocytes and Restores Regulatory T Cells in Kawasaki Disease
Corresponding Author
Keiichi Koizumi
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Address correspondence and reprint requests to Mr Keiichi Koizumi, Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. Email: [email protected]Search for more papers by this authorMinako Hoshiai
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorTakeshi Moriguchi
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorNobuyuki Katsumata
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorTakako Toda
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorHiroaki Kise
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorYohei Hasebe
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorYosuke Kono
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorYuto Sunaga
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorMasashi Yoshizawa
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorAtsushi Watanabe
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorNorikazu Harii
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorJunko Goto
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorKeiko Kagami
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorMasako Abe
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorKenichi Matsuda
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorKanji Sugita
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorCorresponding Author
Keiichi Koizumi
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Address correspondence and reprint requests to Mr Keiichi Koizumi, Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. Email: [email protected]Search for more papers by this authorMinako Hoshiai
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorTakeshi Moriguchi
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorNobuyuki Katsumata
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorTakako Toda
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorHiroaki Kise
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorYohei Hasebe
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorYosuke Kono
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorYuto Sunaga
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorMasashi Yoshizawa
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorAtsushi Watanabe
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorNorikazu Harii
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorJunko Goto
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorKeiko Kagami
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorMasako Abe
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorKenichi Matsuda
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorKanji Sugita
Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan
Search for more papers by this authorAbstract
In Kawasaki disease (KD), the effect of plasma exchange (PE) on immune cells has not been fully elucidated. Therefore, we examined the changes in the number of CD14+ CD16+ activated monocytes, regulatory T (Treg), and T-helper type 17 (Th17) cells in KD patients treated with PE. The percentage of total monocytes and subclasses of lymphocytes, including CD4+ and CD8+ T cells, and CD19+ B cells, showed no significant difference before and after PE. However, the percentage of CD14+ CD16+ monocytes in total leukocytes decreased significantly after PE (1.1% ± 1.5% vs. 2.1% ± 2.3%, P < 0.05). Furthermore, while the percentage of Th17 cells in CD4+ T cells did not change, the percentage of Treg cells in CD4+ T cells increased significantly after PE (11.1% ± 5.1% vs. 8.0% ± 4.4%, P < 0.05). Therefore, PE downregulates activated monocytes and upregulates Treg cells toward normal levels and thus attenuates inflammation in KD.
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