A cross-sectional study examining the prevalence of antibiotic-resistant Cutibacterium acnes isolated from patients with acne in Bangkok, Thailand
Peerada Sermswan
Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand
Search for more papers by this authorRakwaree Sriharat
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorSupichcha Saithong
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorMatchima Laowansiri
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorNutchaya Amornruk
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorDirekrit Chiewchengchol
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorNopadon Noppakun
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
Search for more papers by this authorPravit Asawanonda
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
Search for more papers by this authorCorresponding Author
Tanittha Chatsuwan
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Correspondence
Chanat Kumtornrut, Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Email: [email protected]
Tanittha Chatsuwan, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Chanat Kumtornrut
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
Correspondence
Chanat Kumtornrut, Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Email: [email protected]
Tanittha Chatsuwan, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Email: [email protected]
Search for more papers by this authorPeerada Sermswan
Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand
Search for more papers by this authorRakwaree Sriharat
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorSupichcha Saithong
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorMatchima Laowansiri
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorNutchaya Amornruk
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorDirekrit Chiewchengchol
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorNopadon Noppakun
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
Search for more papers by this authorPravit Asawanonda
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
Search for more papers by this authorCorresponding Author
Tanittha Chatsuwan
Department of Microbiology, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Correspondence
Chanat Kumtornrut, Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Email: [email protected]
Tanittha Chatsuwan, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Chanat Kumtornrut
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
Correspondence
Chanat Kumtornrut, Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Email: [email protected]
Tanittha Chatsuwan, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Email: [email protected]
Search for more papers by this authorAbstract
Cutibacterium acnes is associated with the pathogenesis of acne vulgaris (AV). The relationship between antibiotic-resistant C. acnes and AV remains unclear. The authors aimed to determine the prevalence of antibiotic-resistant C. acnes and investigate the association of acne severity with topical and systemic treatments in patients with acne. Samples were collected of inflammatory and noninflammatory acne, including closed and open comedones and erythematous papules/pustules from the face of patients with mild to severe acne. The samples were cultured under anaerobic conditions for the isolation of C. acnes. Antibiotic susceptibility tests for erythromycin, tetracycline, doxycycline, clindamycin, and trimethoprim/sulfamethoxazole were performed using the agar dilution method. From 153 patients, 143 viable C. acnes samples were isolated (93.5%). They were found resistant to trimethoprim/sulfamethoxazole (143/143, 100%), clindamycin (108/143, 75.5%), erythromycin (105/143, 73.4%), tetracycline (74/143, 51.7%), and doxycycline (73/143, 51.1%). There was no significant correlation between the prevalence of antibiotic resistance and acne severity. High-level resistant C. acnes correlated with higher clinical severity of acne in patients taking doxycycline (τb = 0.3). The present prevalence of antibiotic-resistant C. acnes was high in Thailand. Antibiotic stewardship in AV treatment should be encouraged to prevent further antibiotic resistance crises.
CONFLICT OF INTEREST STATEMENT
The authors have no conflicts of interest to declare including payment for expert testimony.
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