Association between hepatitis C virus infection and subsequent chronic inflammatory skin disease
Sheng-Hsiang Ma
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Search for more papers by this authorYing-Hsuan Tai
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorCorresponding Author
Ying-Xiu Dai
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Correspondence
Mu-Hong Chen, Department of Psychiatry, and Ying-Xiu Dai, Department of Dermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City, Taiwan 11217, ROC.
Emails: [email protected]; [email protected]
Search for more papers by this authorYun-Ting Chang
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Search for more papers by this authorTzeng-Ji Chen
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Search for more papers by this authorCorresponding Author
Mu-Hong Chen
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
Correspondence
Mu-Hong Chen, Department of Psychiatry, and Ying-Xiu Dai, Department of Dermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City, Taiwan 11217, ROC.
Emails: [email protected]; [email protected]
Search for more papers by this authorSheng-Hsiang Ma
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Search for more papers by this authorYing-Hsuan Tai
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for more papers by this authorCorresponding Author
Ying-Xiu Dai
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Correspondence
Mu-Hong Chen, Department of Psychiatry, and Ying-Xiu Dai, Department of Dermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City, Taiwan 11217, ROC.
Emails: [email protected]; [email protected]
Search for more papers by this authorYun-Ting Chang
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Search for more papers by this authorTzeng-Ji Chen
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Search for more papers by this authorCorresponding Author
Mu-Hong Chen
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
Correspondence
Mu-Hong Chen, Department of Psychiatry, and Ying-Xiu Dai, Department of Dermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City, Taiwan 11217, ROC.
Emails: [email protected]; [email protected]
Search for more papers by this authorAbstract
Hepatitis C virus (HCV) infection is associated with several cutaneous manifestations, including lichen planus and psoriasis. However, its association with other chronic inflammatory skin diseases (CISD) remains largely unknown. The aim of this study was to investigate the association between HCV infection and CISD. Participants were recruited from the National Health Insurance Research Database in Taiwan. Altogether 23 509 patients with HCV infection and 94 036 matched controls were included to assess the risk of CISD. A Cox regression model was used for the analyses. Compared with controls, patients with HCV infection had an adjusted hazard ratio (aHR) of 6.34 (95% confidence interval [CI], 5.30–7.58) for CISD after adjustment for potential confounders. Regarding individual CISD, patients with HCV infection had a significantly increased risk of developing lichen planus, psoriasis, vitiligo, alopecia areata, and cutaneous lupus erythematosus. Interferon-based antiviral therapy (IFN-based AVT) was significantly associated with a decreased risk of CISD (aHR = 0.42; 95% CI, 0.28–0.64). Patients with HCV infection had a significantly increased risk of CISD, while IFN-based AVT was associated with a decreased risk. These findings suggest monitoring of CISD in patients with HCV infection.
CONFLICT OF INTEREST
None declared.
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